HRG
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Official Full Name
histidine-rich glycoprotein -
Overview
This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit roset -
Synonyms
HRG;histidine-rich glycoprotein;DKFZp779H1622;Histidine proline rich glycoprotein;Histidine rich glycoprotein;HPRG;HRGP;Thrombophilia due to elevated HRG;OTTMUSP00000045931;histidine-proline-rich glycoprotein;D16jh2;D18020;AI265597;AW413091;THPH11
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- Mammalian Cells
- E.coli
- Wheat Germ
- Human Cells
- Mouse
- In Vitro Cell Free System
- His
- Non
- GST
- T7
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
HRG involved in several pathways and played different roles in them. We selected most pathways HRG participated on our site, such as Dissolution of Fibrin Clot,Hemostasis,Platelet activation, signaling and aggregation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Dissolution of Fibrin Clot | S100A10,SERPINE2,SERPINB8,ANXA2,S100A10A,S100A10B,SERPINF2B,ANXA2A,ANXA2B |
| Response to elevated platelet cytosolic Ca2+ | PLEK,CD9B,STXBP3,SCG3,BRPF3,F13A1B,F13A1A.1,STXBP3A,TFA,CLU |
| Platelet activation, signaling and aggregation | F13A1B,IGF2B,SERPINF2B,SPARC,GAS6,ABHD12,GNA13B,STXBP3,CD9A,FCER1GL |
| Hemostasis | D-AKAP2,GATA6,KIF18A,MMRN1,FN1B,Alb,KIF22,KIF5A,ITGB3A,LRRC16A |
| Platelet degranulation | CALU,CD9B,IGF2B,WDR1,SCG3,BRPF3,MMRN2A,GAS6,SRGN,MMRN1 |
Protein Function
HRG has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity,heme binding,heparan sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HRG itself. We selected most functions HRG had, and list some proteins which have the same functions with HRG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | KDM1B,ACLY,GUCY1B3,CH25HL2,ZC3H7A,HBAE1,RACGAP1,ZNF319,ZFP64,NEURL3 |
| serine-type endopeptidase inhibitor activity | SERPINA12,SERPINA3M,WFDC2,AGT,SERPINE1,SERPINC1,TFPI2,SPINK8,SERPINB13,WFDC10A |
| zinc ion binding | ZMAT3,RORA,TRIM61,FHL2,GTF2H2,NR6A1,KDM4B,ADH5,RC3H2,CA15C |
| cysteine-type endopeptidase inhibitor activity | BIRC7,CTLA2B,BIRC5,SERPINB3,BIRC5B,CST14B.1,NLRC4,CSTA,CST2,AHSG |
| heme binding | NOS1,HBAA,CYP2K22,EPX,CYP8B2,MPO,SUOX,CYP39A1,HBAE1,PTGIS |
| protein binding | NFKBID,CBLB,ATP6V0A4,LPP,ARMCX5-GPRASP2,DSTN,MRFAP1,MAP4K5,DDX3X,TBP |
| heparan sulfate proteoglycan binding | PLA2G2D,UBE4A,Gpc2,GPC5A,Itgam&Itgb2,AZU1,GPC1A,FST,SEMA5A,GPC1B |
| receptor binding | HSD17B4,SSTR3,DAO,SMARCD3,EFNA1,BMP2,LPL,CXCL1,LYN,Itga10&Itgb1 |
| immunoglobulin binding | cgr2b,VWF |
Interacting Protein
HRG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRG here. Most of them are supplied by our site. Hope this information will be useful for your research of HRG.
q99xu0_strp1;RCHY1;q99xu0_strp1;PLSCR1;GAMMAHV.ORF4;GAMMAHV.ORF31;SPRY1;FN1;TNFRSF1A;q99ib8-pro_0000045596;CHRD;RABAC1;d-mannose
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References
- Hu, S; Dai, HB; et al. Silencing EGFR/HER3 signaling with a novel anti-EGFR domain II/IV antibody. CANCER LETTERS 357:374-383(2015).
- Kawakami, H; Okamoto, I; et al. The anti-HER3 antibody patritumab abrogates cetuximab resistance mediated by heregulin in colorectal cancer cells. ONCOTARGET 5:11847-11856(2014).
