GUK1
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Official Full Name
guanylate kinase 1 -
Overview
The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GUK1;guanylate kinase 1;guanylate kinase;GMK;GMP kinase;KGUA_HUMAN;OTTHUMP00000037504;OTTHUMP00000037738;OTTHUMP00000037739;OTTHUMP00000037741;OTTHUMP00000037742;OTTHUMP00000037743;OTTHUMP00000037745;OTTHUMP00000037746;OTTHUMP00000037747;OTTHUMP00000037748;OTTHUMP00000037750;OTTHUMP00000037751
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
Involved Pathway
GUK1 involved in several pathways and played different roles in them. We selected most pathways GUK1 participated on our site, such as Purine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GUK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | MIBP2,PTGS2A,GALNT5,ALDH3A2,OXSM,Aldh1a7,TDO2A,PFKM,ALPI,GLULA |
| Purine metabolism | PDE7B,ADCY1B,ADAL,CECR1A,GUCY1B3,PAPSS2,ADSSL1,CANT1A,HPRT1,PDE1C |
Protein Function
GUK1 has several biochemical functions, for example, ATP binding,guanylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GUK1 itself. We selected most functions GUK1 had, and list some proteins which have the same functions with GUK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanylate kinase activity | CASK,TJP2,MPP2,DLG4,DLG1L,GUK1B,MPP3,DLG2,DLG1,CARD11 |
| ATP binding | KIFC1,FARSA,GALK2,MYH11A,CSK,HSPD1,AURKA,EPHA2,BCKDK,RAF1B |
Interacting Protein
GUK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GUK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GUK1.
UBE2Z;IQCB1
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References
- Wang-Rosenke, Y; Khadzhynov, D; et al. Tyrosine kinases inhibition by Imatinib slows progression in chronic anti-thy1 glomerulosclerosis of the rat. BMC NEPHROLOGY 14:-(2013).
- Ito, H; Morishita, R; et al. Biochemical and morphological characterization of MAGI-1 in neuronal tissue. JOURNAL OF NEUROSCIENCE RESEARCH 90:1776-1781(2012).
