GALNT1
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Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) -
Overview
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. -
Synonyms
GALNT1;UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1);polypeptide N-acetylgalactosaminyltransferase 1;GalNAc T1;protein UDP acetylgalactosaminyltransferase 1;GalNAc transferase 1;GalNAc-T1;GALNT 1;GALT1_HUMAN;Polypeptide GalNAc transferase 1;Polypeptide N acetylgalactosaminyltransferase 1;Polypeptide N-acetylgalactosaminyltransferase 1 soluble form;pp GaNTase 1;pp-GaNTase 1;Protein-UDP acetylgalactosaminyltransferase 1;UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 1;UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1 (GalNAc T1);UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1;UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- Mus musculus
- E.coli
- Insect Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&GFP
Involved Pathway
GALNT1 involved in several pathways and played different roles in them. We selected most pathways GALNT1 participated on our site, such as Mucin type O-Glycan biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mucin type O-Glycan biosynthesis | GALNTL5,GALNT6,GALNTL2,GCNT3,B4GALT5,GALNTL6,GALNTL1,GALNT5,GALNT7,C1GALT1B |
| Metabolic pathways | NDUFA6,FUT5,AFMID,UGT2A2,BCAT1,CPOX,FAXDC2,PIGV,MGAT1,INPP4B |
Protein Function
GALNT1 has several biochemical functions, for example, carbohydrate binding,manganese ion binding,polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT1 itself. We selected most functions GALNT1 had, and list some proteins which have the same functions with GALNT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| polypeptide N-acetylgalactosaminyltransferase activity | GALNTL4,GALNT11,GALNT9,WBSCR17,GALNTL2,GALNT12,C1GALT1C1,GALNT10,GALNT3,GALNT7 |
| carbohydrate binding | CD209B,REG3G,SIGLEC8,NOMO2,PRG3,HBL4,GALNT3,GALNT5,CD69,SIGLEC9 |
| manganese ion binding | GALNT2,ME1,GYLTL1B,PEPD,XPNPEP1,B4GALT7,PRIMPOL,PPM1AA,ABL1,FEN1 |
Interacting Protein
GALNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT1.
SEC23A;Tgfbr1
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References
- Gregersen, VR; Gustavsson, F; et al. Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. JOURNAL OF DAIRY SCIENCE 98:1261-1272(2015).
- Tian, E; Stevens, SR; et al. Galnt1 Is Required for Normal Heart Valve Development and Cardiac Function. PLOS ONE 10:-(2015).
