GABRB3
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Official Full Name
gamma-aminobutyric acid (GABA) A receptor, beta 3 -
Overview
Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines. -
Synonyms
Gamma-aminobutyric acid type A receptors;GABAA receptors;GABRB3;gamma-aminobutyric acid (GABA) A receptor, beta 3;gamma-aminobutyric acid receptor subunit beta-3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- StrepII
- His&GST
- His&Fc&Avi
Involved Pathway
GABRB3 involved in several pathways and played different roles in them. We selected most pathways GABRB3 participated on our site, such as Neuroactive ligand-receptor interaction,Retrograde endocannabinoid signaling,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABRB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | GNG2,KCNN2,PLA2G4A,HTR1F,MAPK1,CYP2J5,MAPK3,PRKACA,ALOX12,GNAO1 |
| Retrograde endocannabinoid signaling | SLC17A8,Adcy4,RIMS1,MAPK11,GABRE,GRIA2,GNG8,GNB1,GABRG3,PLCB3 |
| Nicotine addiction | GABRA2,GABRA3,GABRD,GABRA1,GABRG2,GRIN2D,GRIN3B,GABRR3,SLC17A8,GABRG1 |
| GABAergic synapse | PRKACG,PRKACA,GABRA4,GABRR1,GNAI1,PRKACB,GABRR3,GNG4,GNB4,SLC38A3 |
| Neuroactive ligand-receptor interaction | GRIN3A,CALCRLA,GNRHR2,TAAR12G,PTGER2B,ADORA3,HTR1A,HRH1,GABRB1,MC4R |
Protein Function
GABRB3 has several biochemical functions, for example, GABA-A receptor activity,GABA-gated chloride ion channel activity,contributes_to chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GABRB3 itself. We selected most functions GABRB3 had, and list some proteins which have the same functions with GABRB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to extracellular ligand-gated ion channel activity | GABRR2A,GABRR2,GABRB1,GABRB2,GABRQ,GABRR3A,GABRZ |
| GABA-A receptor activity | GABRR2A,GABRA1,GABRB2,GABRB1,GABRG2,GABRE,GABRD,GABRR2,GABRA6A,GABRZ |
| contributes_to chloride channel activity | GABRZ,GABRB1,GABRR3A,BEST2,BSND,BEST3,GABRQ,BEST4,BEST1,GABRB2 |
Interacting Protein
GABRB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABRB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABRB3.
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References
- Zhao, CJ; Eisinger, BE; et al. Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens. FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8:-(2014).
- Srivastava, S; Cohen, J; et al. A Novel Variant in GABRB2 Associated with Intellectual Disability and Epilepsy. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164A:2914-2921(2014).
