FKBP3
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Official Full Name
FK506 binding protein 3, 25kDa -
Overview
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. -
Synonyms
FKBP3;FK506 binding protein 3, 25kDa;FK506 binding protein 3 (25kD);peptidyl-prolyl cis-trans isomerase FKBP3;FKBP 25;PPIase;FKBP 3;FKBP25;Rotamase;25 kDa FKBP;PPIase FKBP3;OTTHUMP00000178918;immunophilin FKBP25;rapamycin binding protein;25 kDa FK506-binding protein;FK506-binding protein 3 (25kD);FK506-binding protein 25, T-cell;rapamycin-selective 2;FKBP-3;FKBP-25
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Cattle
- Dictyostelium Discoideum
- Rhizopus delemar
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- E. coli
- E.coli expression system
- GST
- His
- Non
- His&SUMO
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| FKBP3-12912H | Recombinant Human FKBP3, GST-tagged | E.coli | Human | GST | 1-224a.a. | |
| FKBP3-6936H | Recombinant Human FKBP3 protein(Ala2-Asp224), GST-tagged | E.coli | Human | GST | 2-224 a.a. | |
| FKBP3-1251Z | Recombinant Zebrafish FKBP3 | Mammalian Cell | Zebrafish | His |
|
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| Fkbp3-1266M | Recombinant Mouse Fkbp3 protein, His-tagged | E.coli | Mouse | His | Ala2~Asp224 |
|
| FKBP3-2026H | Recombinant Human FK506 Binding Protein 3, 25kDa | E.coli | Human | Non |
|
|
| FKBP3-28915TH | Recombinant Human FKBP3 | E.coli | Human | Non | Full L. 1-224 a.a. |
|
| FKBP3-28917TH | Recombinant Human FKBP3, His-tagged | E.coli | Human | His | 49-224 a.a. |
|
| FKBP3-373H | Recombinant Human FKBP3 | Mammalian Cell | Human | His |
|
|
| FKBP3-6209C | Recombinant Chicken FKBP3 | Mammalian Cell | Chicken | His |
|
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| FKBP3-795H | Recombinant Human FKBP3 Protein, His-tagged | E.coli | Human | His |
|
|
| FKBP3-6206HCL | Recombinant Human FKBP3 293 Cell Lysate | HEK293 | Human | Non |
|
|
| FKBP3-2188C | Recombinant Cattle FKBP3 Protein, His-tagged | E.coli | Cattle | His | Ala2-Asp224 |
|
| FKBP3-2921H | Recombinant Human FKBP3 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 2-224aa |
|
| FKBP3-2954H | Recombinant Human FKBP3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| FKBP3-2954H-B | Recombinant Human FKBP3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| FKBP3-3024H | Recombinant Human FKBP3 Protein (Met1-Asp224), N-His tagged | E.coli | Human | His | Met1-Asp224 |
|
| Fkbp3-3026M | Recombinant Mouse Fkbp3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
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| FKBP3-4190H | Recombinant Human FKBP3 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| FKBP3-4804HF | Recombinant Full Length Human FKBP3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 224 amino acids |
|
| FKBP3-9658H | Recombinant Human FKBP3 protein, His-tagged | E. coli | Human | His | 239aa(including fusion tag) |
|
| RFL26959DF | Recombinant Full Length Dictyostelium Discoideum Fk506-Binding Protein 3(Fkbp3) Protein, His-Tagged | E.coli expression system | Dictyostelium Discoideum | His | Full L. Full Length of Mature Protein (20-194) |
|
| RFL36981RF | Recombinant Full Length Rhizopus Oryzae Fk506-Binding Protein 2B(Fkbp3) Protein, His-Tagged | E.coli expression system | Rhizopus delemar | His | Full L. Full Length of Mature Protein (20-209) |
|
Involved Pathway
FKBP3 involved in several pathways and played different roles in them. We selected most pathways FKBP3 participated on our site, such as Integrated Pancreatic Cancer Pathway,Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with FKBP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by HDAC Class I | WDR77,PRMT5,SIRT2,NR2C1,GATA2,SIRT5,TFCP2,SIRT4,SIRT7,GATA1 |
| Integrated Pancreatic Cancer Pathway | LEFTY1,MST1,CST3,MAPK4,MYT1,FST,TOP2A,RB1CC1,JUND,IL11 |
Protein Function
FKBP3 has several biochemical functions, for example, FK506 binding,peptidyl-prolyl cis-trans isomerase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FKBP3 itself. We selected most functions FKBP3 had, and list some proteins which have the same functions with FKBP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | MECP2,LARP1,MYH9,SOSTDC1B,HSP90AB1,TOP1,FRG1,DKC1,MRPS28,ZNF326 |
| receptor activity | NCR3,MED16,MED30,FPR1,Pla2r1,ATRN,TNFRSF11B,LILRB2,KRT1,CD93 |
| peptidyl-prolyl cis-trans isomerase activity | PPIFA,PPIAB,PPIE,PPIC,PPIG,PPIA,PPIAL4C,FKBP10B,PPIL1,FKBP11 |
| FK506 binding | FKBP9,FKBP7,NFATC1,FKBPL,FKBP5,FKBP1AB,FKBP4,FKBP1A,FKBP10,FKBP1B |
| protein binding | RBM23,RGS8,CCDC170,SLAMF1,SH2B2,EIF5,PTPN12,GNPDA1,WBP2,DLX4 |
Interacting Protein
FKBP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FKBP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of FKBP3.
PARP2;MDM2;SRPK1;MCC;HLA-B;TNIK
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