ELK4
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Official Full Name
ELK4, ETS-domain protein (SRF accessory protein 1) -
Overview
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. -
Synonyms
ELK4;ELK4, ETS-domain protein (SRF accessory protein 1);ETS domain-containing protein Elk-4;SAP1;ELK4_HUMAN;ETS domain containing protein Elk4;ETS domain protein;SAP-1;Serum response factor accessory protein 1;SRF accessory protein 1;TCF1;OTTHUMP00000035338;OTTHUMP00000035339
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Zebrafish
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ELK4 involved in several pathways and played different roles in them. We selected most pathways ELK4 participated on our site, such as MAPK signaling pathway,HTLV-I infection,Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ELK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MAPK12B,CDC25B,Fasl,CASP3A,TNFRSF1A,PAK2B,RELA,MAPK8IP3,MAPK9,RAP1B |
| HTLV-I infection | FZD10,IL2RA,MAP3K1,TNF,KAT2B,BCL2L1,WNT8B,WNT9A,PDGFRA,BUB3 |
| Transcriptional misregulation in cancer | PTCRA,LMO2,HOXA9,MLF1,ERG,EYA1,HMGA2,HIST1H3H,PAX3,NFKB1 |
Protein Function
ELK4 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ELK4 itself. We selected most functions ELK4 had, and list some proteins which have the same functions with ELK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | ZNF165,HOXA5A,HSFX1,MTPN,CENPB,GATA2B,POU1F1,TBX3,RXRAA,VENTX |
| chromatin binding | NCOA3,KDM1A,PRKCBP1L,MEN1,SUV39H1,SIRT2,HDAC2,ZGLP1,KDM8,CHD8 |
| transcription factor activity, sequence-specific DNA binding | TFDP1B,ZNF643,ZNF471,SIM1A,BLF,NR5A5,ZNF549,TGIF2,NTNG1,ZFP879 |
| DNA binding | TCF4,NR2F6,ZNF550,GM14478,ASCL4,PURG,SMAD3A,ZHX1,NR1D2B,SIX1A |
| transcription cofactor activity | IRF3,LDB2A,SLC26A3,ZNF710,LDB1B,MXD1,TAF13,LPXN,RFXANK,NSD1 |
| protein binding | XAB2,MAGEB2,MYH7B,PRKCE,ALDH3B1,FANCM,ZFP64,TULP1,ATP5G1,NPAS2 |
| core promoter binding | HNRNPU,INSM1B,E2F1,KDM3A,GTF2B,E2F7,SFPQ,RELB,GATA1,SFPI1 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXG1C,GATA6,KLF11,NPAS4,SP3A,HIF1AB,ERG,FOXL1,FOXD1L,PLAGX |
Interacting Protein
ELK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ELK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ELK4.
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References
- Ren, GP; Zhang, YL; et al. Transcription-Mediated Chimeric RNAs in Prostate Cancer: Time to Revisit Old Hypothesis?. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY 18:615-624(2014).
- Weinl, C; Wasylyk, C; et al. Elk3 Deficiency Causes Transient Impairment in Post-Natal Retinal Vascular Development and Formation of Tortuous Arteries in Adult Murine Retinae. PLOS ONE 9:-(2014).
