EDAR
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Official Full Name
ectodysplasin A receptor -
Overview
EDAR is a 49 kDa novel receptor of the TNFR family with one phosphorylation site at serine 324 residue and one death domain near the C-terminus (358-431 aa). Mutations in EDAR have been found in several families with autosomal hypohidrotic ectodermal dysp -
Synonyms
EDAR;ectodysplasin A receptor;DL, ectodysplasin 1, anhidrotic receptor , ED3;tumor necrosis factor receptor superfamily member EDAR;ED1R;ED5;EDA1R;EDA3;EDA-A1 receptor;downless homolog;ectodysplasin-A receptor;downless, mouse, homolog of
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rat
- Cynomolgus
- E.coli
- Mammalian cells
- HEK293
- Human Cell
- Mammalian Cell
- CHO
- Human cells
- Wheat Germ
- HEK293T
- GST
- Non
- His
- Fc
- His&Flag&StrepII
- His&Fc&Avi
- Myc&DDK
Involved Pathway
EDAR involved in several pathways and played different roles in them. We selected most pathways EDAR participated on our site, such as Cytokine Signaling in Immune system,Cytokine-cytokine receptor interaction,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with EDAR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNFs bind their physiological receptors | EDARADD,EDA |
| Cytokine Signaling in Immune system | TRIM8,TRIM46,FGF18B,EIF4A2,SPTBN2,TRIM48,HBEGF,USP18,KPNA5,TRIM68 |
| Integrated Breast Cancer Pathway | USP15,LGALS13,DHTKD1,DAG1,DCAKD,RPP38,UBE2F,SELK,ALKBH1,PLK3 |
| Cytokine-cytokine receptor interaction | IL12B,TNFB,LEPB,CXCL6,BMP7A,EGFRA,TNFRSF17,Flt3l,IL19,KITLGB |
| Immune System | EDARADD,TRIM31,TRIM10,TRIM69,CFD,TRIM56,CISH,PAG1,GM11711,CASP2 |
| TNFR2 non-canonical NF-kB pathway | EDARADD,EDA |
Protein Function
EDAR has several biochemical functions, for example, protein binding,receptor activity,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDAR itself. We selected most functions EDAR had, and list some proteins which have the same functions with EDAR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PML,C1orf109,RPP30,FAM193B,CD86,SLC4A1AP,ZHX1,BRAP,RAI1,DSP |
| transmembrane signaling receptor activity | TLR2-1,GPR126,GHRHRA,LILRA1,TNFRSF11A,TLR7,OR2A4,OR4F29,ICAM1,OR12D3 |
| receptor activity | GRIN1B,RET,CXCR3,ADIPOR1B,CADM1,GRIN2BB,ITGB4,TLR4,NOTCH1B,PAQR5A |
Interacting Protein
EDAR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDAR here. Most of them are supplied by our site. Hope this information will be useful for your research of EDAR.
Traf1;Traf2;TRAF3;EDARADD;EDA;MAP3K14
EDAR Related Signal Pathway
Resources
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References
- Hill, G; Headon, D; et al. Pharmacological Activation of the EDA/EDAR Signaling Pathway Restores Salivary Gland Function following Radiation-Induced Damage. PLOS ONE 9:-(2014).
- Kowalczyk-Quintas, C; Schuepbach-Mallepell, S; et al. Pharmacological Stimulation of Edar Signaling in the Adult Enhances Sebaceous Gland Size and Function. JOURNAL OF INVESTIGATIVE DERMATOLOGY 135:359-368(2015).
