DUSP3
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Official Full Name
dual specificity phosphatase 3 -
Overview
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. -
Synonyms
DUSP3;dual specificity phosphatase 3;vaccinia virus phosphatase VH1 related , VHR;dual specificity protein phosphatase 3;vaccinia H1-related phosphatase;vaccinia virus phosphatase VH1-related;dual specificity protein phosphatase VHR;serine/threonin
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- E.coli
- Insect Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
DUSP3 involved in several pathways and played different roles in them. We selected most pathways DUSP3 participated on our site, such as Activated TLR4 signalling,ERK/MAPK targets,ERKs are inactivated, which may be useful for your reference. Also, other proteins which involved in the same pathway with DUSP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAP kinase activation in TLR cascade | TNIP2,NOD1,DUSP3B |
| Innate Immune System | DEFB106A,DEFB4B,FCN2,NCKAP1,TREX1,TAX1BP1,S100B,NLRP4C,ART1,DDOST |
| MAPK signaling pathway | FGF4,MAP4K2,NF1,NTRK2B,PPM1NB,RAF1,ECSIT,RAC2,MKNK2B,DDIT3 |
| MAPK targets/ Nuclear events mediated by MAP kinases | DUSP3B |
| Immune System | ATG7,CYBB,ABI2,TRIM26,KIF11,LILRB5,CD300LF,FAM49BA,CTSC,KIF26A |
| Activated TLR4 signalling | PELI3,CHST13,AGER,MAP3K8,IRAK3,CREB1,JUN,APPA,DUSP6,TNIP2 |
| ERKs are inactivated | DUSP3B |
| ERK/MAPK targets | DUSP3B |
Protein Function
DUSP3 has several biochemical functions, for example, MAP kinase phosphatase activity,protein kinase binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DUSP3 itself. We selected most functions DUSP3 had, and list some proteins which have the same functions with DUSP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine/serine/threonine phosphatase activity | DUSP22A,LRP8,PTP4A3,NT5DC3,SSH3,SACM1LA,DUSP21,CDC14A,DUSP14,CDKN3 |
| protein tyrosine phosphatase activity | PTPRFB,PTPRM,PTPN11B,SSH2B,PTEN,DUSP8A,UBASH3B,PTPN1,CDC14AA,SSH3 |
| MAP kinase phosphatase activity | DUSP3B,DUSP10 |
| protein kinase binding | RNF138,NR4A3,PTPN23,EPHA1,CCNT2A,TRAF2,LATS1,CD226,BAG5,TNNI3 |
Interacting Protein
DUSP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUSP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUSP3.
MAPK3;MAPK1;MCC;HLA-B;CASK;BNIP3L;NEUROD1;pi3p
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