DEFA6
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Official Full Name
defensin, alpha 6, Paneth cell-specific -
Overview
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. -
Synonyms
DEFA6;defensin, alpha 6, Paneth cell-specific;defensin-6;DEF6;HD 6;alpha 6;DEF6_HUMAN;DEFA 6;Defensin 6;Defensin alpha 6;Defensin alpha 6 Paneth cell specific;Defensin;HD6;OTTHUMP00000115425;HD-6
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- E.Coli or Yeast
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- His&GST
- GST
- Non
- His
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
DEFA6 involved in several pathways and played different roles in them. We selected most pathways DEFA6 participated on our site, such as Alpha-defensins,Defensins,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with DEFA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defensins | DEFB121,DEFB1,DEFA5,DEFB4B,DEFB4A,DEFB106A,DEFB129,CCR6,DEFB125,DEFB116 |
| Immune System | SIGLEC7,TRIM45,SRMS,KIF5B,POLR3G,ASB7,MX2,BTR09,EIF4G2,LILRB2 |
| Innate Immune System | PELI2,DEFB4A,Txn1,POLR3F,TNIP2,DEFA3,BTR30,CRCP,IRF2,CD300E |
| Alpha-defensins | ART1,DEFA5,DEFA3,DEFA1 |
Protein Function
DEFA6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DEFA6 itself. We selected most functions DEFA6 had, and list some proteins which have the same functions with DEFA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CTLA4,CCDC167,FBXO44,RAD23B,COA5,ALKBH4,NDUFS3,TMEM174,CX3CR1,EN1 |
Interacting Protein
DEFA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DEFA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of DEFA6.
UBQLN1;UBQLN1
Resources
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References
- Xiao, L; Crabb, DM; et al. Suppression of Antimicrobial Peptide Expression by Ureaplasma Species. INFECTION AND IMMUNITY 82:1657-1665(2014).
- Lucero, CM; Junecko, BF; et al. Macaque Paneth Cells Express Lymphoid Chemokine CXCL13 and Other Antimicrobial Peptides Not Previously Described as Expressed in Intestinal Crypts. CLINICAL AND VACCINE IMMUNOLOGY 20:1320-1328(2013).
