Ddr2
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Official Full Name
discoidin domain receptor tyrosine kinase 2 -
Overview
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5 UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] -
Synonyms
DDR2;discoidin domain receptor tyrosine kinase 2;TKT;MIG20a;NTRKR3;TYRO10;discoidin domain-containing receptor 2;tyrosylprotein kinase;hydroxyaryl-protein kinase;discoidin domain receptor 2;tyrosine-protein kinase TYRO10;CD167 antigen-like family member B;cell migration-inducing protein 20;migration-inducing gene 16 protein;receptor protein-tyrosine kinase TKT;discoidin domain receptor family, member 2;neurotrophic tyrosine kinase receptor related 3;neurotrophic tyrosine kinase, receptor-related 3;discoidin domain-containing receptor tyrosine kinase 2
Recombinant Proteins
- Mouse
- Cynomolgus
- Human
- Rhesus macaque
- Rat
- HEK293
- E.coli
- Mammalian cells
- Sf9 Insect Cell
- Human Cell
- Insect Cell
- Wheat Germ
- Insect Cells
- HEK293T
- In Vitro Cell Free System
- His
- Fc
- GST
- Non
- Myc&DDK
- His&GST
- His&Fc
- Flag
- His&T7
- His&Flag
- His&Fc&Avi
Involved Pathway
Ddr2 involved in several pathways and played different roles in them. We selected most pathways Ddr2 participated on our site, such as Endochondral Ossification,Extracellular matrix organization,Non-integrin membrane-ECM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ddr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-integrin membrane-ECM interactions | DDR1,LAMC3,TTR,DMD,TRAPPC4 |
| Endochondral Ossification | COL2A1,SOX9A,SOX5,COL10A1,RUNX3,PTH,MMP13,ADAMTS4,FRZB,NKX3.2 |
| Extracellular matrix organization | COL5A3A,ADAM8A,COL11A1B,ADAM9,NID2,ADAMTS8,MFAP4,LOXL2,FMOD,F11R.2 |
Protein Function
Ddr2 has several biochemical functions, for example, ATP binding,collagen binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ddr2 itself. We selected most functions Ddr2 had, and list some proteins which have the same functions with Ddr2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | USP6,MAP2K4,DTNB,ABCE1,CRHR2,GTF3C4,RWDD2B,EIF4H,HSPA4,BEGAIN |
| ATP binding | RLN1,FLAD1,MYH11,ATP7A,NTRK1,P2RX4,MYO7AA,AARS2,SMCHD1,PIF1 |
| collagen binding | GPR56,C1QTNF1,CD44,SRGN,TGFBI,PAK1,PCOLCE2,PDGFA,DCN,SERPINH1B |
| protein tyrosine kinase collagen receptor activity | DDR1 |
| transmembrane receptor protein tyrosine kinase activity | NTRK2B,TEK,IGF1RB,MUSK,EK1,TIE1,EPHA2A,RYK,ERBB4A,NPTNB |
Interacting Protein
Ddr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ddr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ddr2.
COL11A2;HSP90AB1;SHC1;imatinib;N/A;SRC;CBLB;CDC37;CHORDC1;GOLT1B
Resources
Research Area
Cancer Drug TargetsOther Cytokines & Receptors
Receptor Tyrosine Kinases (RTKs)
Mesenchymal Cells and EMT
Related Services
Related Products
References
- Thunnissen, E; van der Oord, K; et al. Prognostic and predictive biomarkers in lung cancer. A review. VIRCHOWS ARCHIV 464:347-358(2014).
- Carafoli, F; Hohenester, E; et al. Collagen recognition and transmembrane signalling by discoidin domain receptors. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1834:2187-2194(2013).
