DCLK1
-
Official Full Name
doublecortin-like kinase 1 -
Overview
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities. -
Synonyms
DCLK1;doublecortin-like kinase 1;serine/threonine-protein kinase DCLK1;doublecortin-like and CAM kinase-like 1;double cortin and calcium/calmodulin-dependent protein kinase-like 1;Ania4;Cpg16;Dcamkl1
Recombinant Proteins
- Human
- Chicken
- Mouse
- Sf9 Insect Cell
- Insect Cell
- E.coli
- Insect Cells
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Insect (sf21)
- Mammalian cells
- GST
- His
- His&GST
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
DCLK1 involved in several pathways and played different roles in them. We selected most pathways DCLK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DCLK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
DCLK1 has several biochemical functions, for example, ATP binding,protein kinase activity,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCLK1 itself. We selected most functions DCLK1 had, and list some proteins which have the same functions with DCLK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | PRKD1,ADCK2,VRK1,CLK4,STK32B,RPS6KC1,SMOK2B,SGK2B,CSNK1G2B,TTN |
| protein kinase activity | HIPK3,GRK1,TSSK5,AVP,SBK1,PIK3CG,ERBB3B,NPR2,NLK1,CDKL5 |
| receptor signaling protein activity | FCAR,FCGR1A,BAG1,DOK1,GNAZ,RGS12,TIAM2,KLK1B4,TRAIP,CD19 |
| ATP binding | MYO1G,HSPA9,PRKAG1,MYO19,CDKL4,JAK3,HSPA4A,WARS,FBXO18,ACSF2 |
Interacting Protein
DCLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DCLK1.
xmd8-92;MYC
Resources
Related Services
Related Products
References
