CYLD
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Official Full Name
cylindromatosis (turban tumor syndrome) -
Overview
CYLD is a cytoplasmic deubiquitinating enzyme encoded by a tumor suppressor gene altered in individuals diagnosed with cylindromatosis, a genetic condition characterized by benign tumors of skin appendages. Functional CYLD deubiquitinase regulates inflamm -
Synonyms
CYLD;cylindromatosis (turban tumor syndrome);CYLD1;ubiquitin carboxyl-terminal hydrolase CYLD;KIAA0849;ubiquitin specific peptidase like 2;USPL2;ubiquitin thioesterase CYLD;deubiquitinating enzyme CYLD;ubiquitin thiolesterase CYLD;ubiquitin-spec
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Sf21 Cells
- Mammalian Cells
- Wheat Germ
- HEK293
- Insect Cells
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
CYLD involved in several pathways and played different roles in them. We selected most pathways CYLD participated on our site, such as Canonical NF-kappaB pathway,Death Receptor Signalling,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYLD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Immune System | TRIM5,GBP6,EDARADD,ASB17,BAIAP2,CD180,SH3RF1,TRIM39,TREX1,NPEPPS |
| Death Receptor Signalling | OTULIN,RBCK1,USP2,SHRPRBCK1R,RNF31,OTUD7B,OTULINB,FAM105B,TAX1BP1B,SHARPIN |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | PANX1B,BTR22,BTR29,PANX1,TXNIP,CASP4,BTR02,BTR18,BTR06,BTR16 |
| Innate Immune System | CRP,ABI1A,CFHL3,PANX1A,TREM1,MGC174155,PPAPDC1A,NLRP4C,NLRC5,MGC174152 |
| Canonical NF-kappaB pathway | MALT1 |
| Negative regulators of RIG-I/MDA5 signaling | HERC5,NLRC5,TAX1BP1B,RNF135,TAX1BP1,RNF216,PCBP2 |
| NOD1/2 Signaling Pathway | CASP4 |
| Osteoclast differentiation | RELA,NCF4,IFNG,TNFSF11,PIK3CA,LILRB5,PPP3R1,FCGR2C,TNFRSF1A,CSF1R |
Protein Function
CYLD has several biochemical functions, for example, Lys63-specific deubiquitinase activity,proline-rich region binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYLD itself. We selected most functions CYLD had, and list some proteins which have the same functions with CYLD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | CDK5R1,AGTR1A,CACNB3,TRIM22,SYN1,AP2A2,PTPN6,AXIN1,CDC25B,JIP1 |
| Lys63-specific deubiquitinase activity | ATXN3,YOD1 |
| ubiquitin-specific protease activity | OTUD3,EIF3F,IWS1,USP33,FMNL3,OTUD5,OTUB1B,DUB1,USP17L2,USP7 |
| protein binding | MARCKSL1,PARD6A,RAG1,CCT3,BANK1,RFC2,FAM46D,CTCFL,SHPRH,APAF1 |
| proline-rich region binding | NEDD4,FAM59A,PRPF40A,APBB1,YAP1,ABI2,ITSN1,WBP4,RABAC1,CSK |
| zinc ion binding | ISL1,VPS41,MKRN1,PJA1,RNF112,RNF181,PRKCBP1L,EHMT1,PGLYRP4,PAPLN |
Interacting Protein
CYLD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYLD here. Most of them are supplied by our site. Hope this information will be useful for your research of CYLD.
TUBA1A;HDAC6;DDX58;UBC;ub6l2_human;MGEA5;CAMK2D;IKBKE;MAVS;SPATA2L;CEP192
Resources
Research Area
Deubiquitinating Enzymes (DUBs)Post-translational Modification of NFkB/IkB
G1 (Restriction) Checkpoints
Related Services
Related Products
References
- Thein, S; Pham, A; et al. MK regulates the deubiquitinase CYLD at the postsynaptic density. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 450:550-554(2014).
- Guo, JY; Shinriki, S; et al. Hypoxia suppresses cylindromatosis (CYLD) expression to promote inflammation in glioblastoma: possible link to acquired resistance to anti-VEGF therapy. ONCOTARGET 5:6353-6364(2014).
