Ctse
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Official Full Name
cathepsin E -
Overview
The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. -
Synonyms
CTSE;cathepsin E;CATE;CATE_HUMAN;Cathepsin E form II;Erythrocyte membrane aspartic proteinase;OTTHUMP00000034345;OTTHUMP00000034346;slow-moving proteinase
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- E.coli
- Mammalian Cells
- Wheat Germ
- Human Cells
- In Vitro Cell Free System
- His
- GST
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
Ctse involved in several pathways and played different roles in them. We selected most pathways Ctse participated on our site, such as Adaptive Immune System,Immune System,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ctse were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MHC class II antigen presentation | MGC174857,OSBPL1A,ACTR1B,KIF26A,DCTN6,IFI30,DYNC1I1,MGC174152,MGC174155,KIF3B |
| Lysosome | AP3M1,LAPTM4A,IDS,DNASE2,CTSA,CTSSB.1,NPC2,AP3M2,ENTPD4,ABCB9 |
| Immune System | SIGLEC9,UNC93B1,TRIM56,OSCAR,LILRA2,MICA,LAIR1,ASB18,UFL1,SPSB4 |
| Adaptive Immune System | UBE2L6,FGF8B,UBA5,LRR1,WWP1,AP2M1,CHUK,OSCAR,AKT3,LRRC41 |
Protein Function
Ctse has several biochemical functions, for example, aspartic-type endopeptidase activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ctse itself. We selected most functions Ctse had, and list some proteins which have the same functions with Ctse. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | TOP2A,CEBPE,GRHPR,IGJ,RPS19,NKX2-5,PDXK,ADD2,ECE1,Il6ra |
| aspartic-type endopeptidase activity | PIP,SPPL2,REN,NRIP3,BACE2,PGA4,BACE1,ANK2B,PSEN2,NRIP2 |
Interacting Protein
Ctse has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ctse here. Most of them are supplied by our site. Hope this information will be useful for your research of Ctse.
BAG6;EMG1
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References
- Zhang, Q; Zhao, XZ; et al. Expression and purification of soluble human cystatin C in Escherichia coli with maltose-binding protein as a soluble partner. PROTEIN EXPRESSION AND PURIFICATION 104:14-19(2014).
- Walker, E; Gopalakrishnan, R; et al. Microscopic Detection of Quenched Activity-Based Optical Imaging Probes Using an Antibody Detection System: Localizing Protease Activity. MOLECULAR IMAGING AND BIOLOGY 16:608-618(2014).
