CKM
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Official Full Name
creatine kinase, muscle -
Overview
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. -
Synonyms
CK-MM, Skeletal;CKMM;M-CK;CKM;creatine kinase M-type;creatine kinase-M;creatine kinase M chain
Recombinant Proteins
- Human
- Rat
- Chicken
- Dog
- Mouse
- Pig
- Cat
- Horse
- Rabbit
- E.coli
- Wheat Germ
- Mammalian Cell
- P.pastoris
- HEK293
- Human Cardiac
- Human
- Mammalian cells
- E. coli
- In Vitro Cell Free System
- Yeast
- Porcine Heart
- Human Heart
- Human Skeletal Muscle
- HEK293T
- Mouse Skeletal Muscle
- Rat Skeletal Muscle
- His
- His&Fc
- GST
- Non
- His&GST
- His&Fc&Avi
- Flag
- C-His&Flag
- His&Strep
- Myc&DDK
Involved Pathway
CKM involved in several pathways and played different roles in them. We selected most pathways CKM participated on our site, such as Arginine and proline metabolism,Creatine metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CKM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ALPL,CYP3A41B,B3GALNT1,SAT1A.1,ITGB1BP3,DCT,EPHX2,PCYT1AA,ATP5G3,ACSBG2 |
| Arginine and proline metabolism | DAO.3,ALDH1B1,ALDH2.1,P4HA2,NOS1,AZIN2,PYCRL,AGMAT,Ckmm,NOS2 |
| Urea cycle and metabolism of amino groups | LSM1,CKB |
| Metabolism of polyamines | SLC25A2,NQO1,PAOX,OAZ2B,CKMT2A,NAGS,OAZ1,SLC6A12,OAZ3,CKMT2 |
| Metabolism of amino acids and derivatives | SLC25A2,OAZ1,ACMSD,AMD2,SAT1B,DIO2,CKB,OAZ2B,CKMT2A,BCKDK |
| Metabolism | AMD2,AKR1C4,DHCR24,UGT1B7,CEPT1,SLC25A1A,ETFB,LMF1,KHK,COL4A3BP |
| Creatine metabolism | LSM1,CKMT1B,CKMT2,SLC6A12,SLC6A8,CKBA,CKB,CKMT2A,CKMB,SLC6A7 |
| Regulation of retinoblastoma protein | BRD2,SMARCB1,AATF,BGLAP,CBX4,GSC,ATF7,ELF1,MYOD1 |
Protein Function
CKM has several biochemical functions, for example, ATP binding,creatine kinase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CKM itself. We selected most functions CKM had, and list some proteins which have the same functions with CKM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | NAV2,DYRK3,MYO10,PDK3,ABCC5,SMARCAL1,EPHA7,SNRKB,TNNI3K,CAMK2G |
| creatine kinase activity | CKB,CKMT2,MAP4K4,Ckmm,CKMT1,CKBB,CKMT1A,CKMT1B |
| protein binding | PNMA1,CTDSP1,CD6,NTF3,MTPAP,RAB11FIP2,EVI5L,RCHY1,DNA2,ANKRD32 |
Interacting Protein
CKM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CKM here. Most of them are supplied by our site. Hope this information will be useful for your research of CKM.
ASB9;NOS1AP;IQCB1
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