CDKN2C
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Official Full Name
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -
Overview
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008] -
Synonyms
CDKN2C;cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4);p18;INK4C;p18-INK4C;cyclin-dependent kinase 4 inhibitor C;p18-INK6;CDK6 inhibitor p18;cyclin-dependent inhibitor;cyclin-dependent kinase 6 inhibitor p18
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- T7
- Non
- Strep
- DDK
- Myc
- Avi
- Fc
Involved Pathway
CDKN2C involved in several pathways and played different roles in them. We selected most pathways CDKN2C participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cyclin D associated events in G1 | PIANP,CDKN2D,E2F4,CKS1B,CDK7,CDKN2B |
| G1 Phase | CDKN2D,CDKN2B,E2F4,PIANP,CKS1B |
| Cell Cycle, Mitotic | NINL,SETB,PMF1,DULLARD,CENPC1,ARPP19,MAPRE1A,GOLGA2,ACTR1A,CEP57 |
| Cellular Senescence | E2F2,CDKN2D,RBB4L,TINF2,CDK4,HIRA,CBX8A,POT1,PHC1,RBBP7 |
| E2F transcription factor network | CES1,YY1,UXT,CES5A,PRMT5,RBBP8,MYBL2,HIC1,CEBPA,DHFR |
| Cellular responses to stress | HSPA14,TXN,DYNLL2B,LC3,DNAJC7,ACD,NUP50,RRAGB,DYNLL2A,LAMTOR2 |
| Cell cycle | NCAPH,RAD9B,LIN9,WEE1,CDC20,MCM3L,CSNK2A2,HUS1,CEP78,LEMD3 |
Protein Function
CDKN2C has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity,protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN2C itself. We selected most functions CDKN2C had, and list some proteins which have the same functions with CDKN2C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MTAP1B,PPP1R1A,RABGGTB,UBE4A,CHMP4B,FAM192A,CLASP1,CHRNB2,ARL11,CD79A |
| protein kinase binding | GDF3,PGAM1,TCF7L2,NPM1,CAV2,CCNB1,DAXX,ZC3HC1,TRAF4,SMAD1 |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | CDKN1C,KAT2B,HEXIM2,CDKN2A,CDKN2D,HEXIM1,CDKN1BB,Casp3,INCA1,CDKN1A |
Interacting Protein
CDKN2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDKN2C here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN2C.
CDK4;CDK6;AHCYL1
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