CD82

What is CD82 Protein?

CD82 is a protein found in cell membranes, part of the tetraspanin family. It acts like a helper or gatekeeper, working with other proteins to steer different cell functions. Known for affecting how cells stick together and talk to each other, CD82 plays a role in cell movement and cancer spread. By managing signals and teaming up with other proteins, CD82 affects how cells react to their surroundings, which is why it's important in cancer research and treatment development.

What is the Function of CD82 Protein?

CD82 is a protein that plays a key role in how cells interact and communicate. It's like a manager that helps control cell adhesion, which is how cells stick to each other, and migration or movement. This protein can influence immune responses and has a hand in stopping cancer cells from spreading. By forming clusters with other proteins, CD82 helps regulate signals sent to cells, impacting how they grow and develop. It's an important focus in cancer research because it can potentially prevent tumors from invading other parts of the body.

CD82 Related Signaling Pathway

CD82 is involved in several signaling pathways that dictate how cells behave. Think of it as a traffic cop for cell communication. This protein helps in managing signals related to cell growth, adhesion, and movement, especially in cancer cells where it can slow down their spread. CD82 interacts with proteins like EGFR and c-Met, affecting pathways that control cell survival and proliferation. By influencing these pathways, CD82 plays a part in immune response and can hinder tumor growth and metastasis, making it a critical focus for researchers looking to develop cancer therapies. Understanding these pathways gives insight into how cells make decisions and how we might steer those decisions in diseases like cancer.

CD82 Related Diseases

CD82 is linked to several diseases, mainly because of its role in regulating cell behavior. In cancer, CD82 often acts as a suppressor, meaning it helps prevent cancer cells from spreading to other parts of the body. When CD82 isn't functioning properly or its levels decrease, it can lead to more aggressive tumor growth and metastasis, making it a key focus in cancer studies. Beyond cancer, CD82 is also tied to immune-related diseases. Since it plays a part in how cells communicate and stick together, changes in CD82 levels or function can affect immune system responses, possibly leading to disorders where the immune system doesn't work quite right. Understanding CD82's role offers potential pathways for developing treatments for these conditions.

Bioapplications of CD82

CD82 has some interesting bioapplications, especially in the field of cancer research. Scientists are looking into how they can use CD82 to halt the spread of cancer, as it naturally acts to keep cancer cells from moving around the body. By understanding how CD82 works, researchers aim to develop therapies that mimic or boost its tumor-suppressing abilities. Another potential use is in immunotherapy, where CD82 could help modulate immune responses for better targeting of diseases. Since CD82 interacts with various proteins and affects how cells adhere and communicate, it has the potential to be a part of treatments for diseases where cell interaction goes awry. The study of CD82 is opening up new paths for medical therapies, especially those focused on stopping cancer and improving immune function.

Case Study 1: Zhou B. et al. Cancer Res. 2004

KAI1/CD82, a protein that helps stop cancer spread, belongs to the tetraspanin family. It's modified through palmitoylation, aiding cluster formation, but its effect on cell functions was unclear. In PC3 prostate cancer cells, KAI1/CD82 undergoes this modification, crucial for its role in reducing cell movement and spread. When KAI1/CD82 isn't palmitoylated, its ability to inhibit cancer cell migration is reduced. This modification affects KAI1/CD82's location in the cell and interaction with other proteins, vital for its function. Palmitoylation influences structures related to cell movement, showing it's essential for KAI1/CD82 to inhibit cancer cell spread effectively.

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  Fig1. Mapping the palmitoylation sites of KAI1/CD82.
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  Fig2. Palmitoylation is involved in KAI1/CD82-induced down-regulation of p130CAS-CrkII coupling.

Case Study 2: Bu J. et al. Acta Biochim Biophys Sin (Shanghai). 2022

CD82 influences EGFR and c-Met functions, with palmitoylation aiding their clustering and signaling. Researchers don't fully know how this affects EGFR and c-Met's location and stability. In breast cancer, they found CD82 mutations at Cys5+Cys74 make EGFR enter cells, binding directly to CD82 with tubulin's help, ending up in the recycling endosome. Examining Rab11a and FIP2 showed the EGFR/CD82/Rab11a/FIP2 complex boosts EGFR recycling, leading to both EGFR and CD82 reappearing on the cell surface.

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  Fig3. The immunoblotting results showed the physical interaction relationship between CD82 and Lamp1, Rab7a and Rab11a.
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  Fig4. The IP results showed that FIP2 can directly bind to Rab11a and CD82.

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  Fig1. Schematic of CD82 regulation and functions. (Yien Che Tsai, 2011)
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  Fig2. Tspans that suppress digestive system tumor cell metastasis. (Shijie Shao, 2024)

CD82 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD82 itself. We selected most functions CD82 had, and list some proteins which have the same functions with CD82. You can find most of the proteins on our site.

Function	Related Protein
protein binding	NKD1,CD69,OTX2,NLGN4X,DNAJC27,NCKAP1L,GNPDA2,MEMO1,GPN1,UQCRC2

CD82 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD82 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD82.

VANGL1;CD19;NFKB1;NUP88;q9wmx2-pro_0000037550