CD3G
-
Official Full Name
CD3g molecule, gamma (CD3-TCR complex) -
Overview
The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. -
Synonyms
CD3G;CD3g molecule, gamma (CD3-TCR complex);CD3g antigen, gamma polypeptide (TiT3 complex);T-cell surface glycoprotein CD3 gamma chain;T-cell receptor T3 gamma chain;CD3g molecule, epsilon (CD3-TCR complex);T-cell antigen receptor complex, gamma sub
Recombinant Proteins
- Human
- Rat
- Mouse
- Cynomolgus
- Rhesus macaque
- Mus musculus
- Wheat Germ
- Mammalian Cell
- HEK293
- E.coli
- Yeast
- Mammalian cells
- E.coli expression system
- GST
- His
- Non
- Fc
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
CD3G involved in several pathways and played different roles in them. We selected most pathways CD3G participated on our site, such as Hematopoietic cell lineage,T cell receptor signaling pathway,Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD3G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | IKBKB,FZD10,IL15RA,AKT2,TGFBR2,POLD2,NFYB,RRAS,TNF,KAT2A |
| Measles | EIF3H,MAP3K7,TACR1,CCND1,TLR9,OAS1,IFNA10,IFIH1,IL4,IRAK1 |
| T cell receptor signaling pathway | AKT2,MAP2K7,ZAP70,Il2,CD8A,IFNG,PPP3CB,GRAPA,GRAP2,GRB2 |
| Chagas disease (American trypanosomiasis) | CD3D,IRAK1,CALR,PLCB4,GNAI3,SMAD3,PPP2CB,AKT2,IL1B,MYD88 |
| Hematopoietic cell lineage | IL2RA,CD36,GM13305,EPOR,ANPEP,IL6,CR2,CD37,ITGB3,CD59A |
Protein Function
CD3G has several biochemical functions, for example, T cell receptor binding,protein heterodimerization activity,receptor signaling complex scaffold activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD3G itself. We selected most functions CD3G had, and list some proteins which have the same functions with CD3G. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | NPAS4,JAM3,BTBD11A,H3F3C,TYRP1,KCNH1,ATF6,ADD2,ODZ4,RAB3GAP2 |
| T cell receptor binding | CD3E,DOCK2,H2-Q10,HLA-A,FYN,CD1d1,EPS8L1 |
| transmembrane signaling receptor activity | OR103-4,EGFR,TLR2,LGR6,CALCRLA,KLRC2,TRPV1,LYVE1,VIPR1B,TLR2-2 |
| receptor signaling complex scaffold activity | SPAG9A,GRIP1,SHANK1,GRIP2A,CARD10,NUP62,LDLRAP1,MAPK8IP3,NCK2,G3BP2 |
Interacting Protein
CD3G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD3G here. Most of them are supplied by our site. Hope this information will be useful for your research of CD3G.
CD3E
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesConventional/Classical Dendritic Cells
T Cell Antigen Recognition
Lymphoid Lineage Markers
T Follicular Helper (Tfh) Cells
Th1 Cells
Th17 Cells
Th2 Cells
Th22 Cells
Th9 Cells
Related Services
Related Products
References
