CD247
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Official Full Name
CD247 Molecule -
Overview
The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
CD247;CD247 molecule;T3Z;CD3H;CD3Q;CD3Z;TCRZ;CD3-ZETA;Preferred;T-cell surface glycoprotein CD3 zeta chain;OTTHUMP00000032543;OTTHUMP00000032544;CD247 antigen, zeta subunit;T-cell receptor T3 zeta chain;CD3Z antigen, zeta polypeptide (TiT3 complex);T-cell antigen receptor complex, zeta subunit of CD3
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Zebrafish
- Chicken
- Rhesus macaque
- Sheep
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Mammalian cells
- Human Cells
- E. coli
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- GST
- Non
- His
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CD247 involved in several pathways and played different roles in them. We selected most pathways CD247 participated on our site, such as Natural killer cell mediated cytotoxicity,T cell receptor signaling pathway,Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD247 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | SYK,ICAM1,PLCG1,PIK3CA,FASLG,ITGAL,GRB2,Raet1a,IFNA21,HCST |
| T cell receptor signaling pathway | RELA,MAPK3,CD3G,CD3D,PAK1,NFKBIA,MAPK11,MAP2K2,GRAPA,MAPK13 |
| Chagas disease (American trypanosomiasis) | MAPK8,TICAM1,TNFRSF1A,TNF,Fasl,IFNGR1,MYD88,PIK3R5,GNAI3,GNAQ |
Protein Function
CD247 has several biochemical functions, for example, identical protein binding,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD247 itself. We selected most functions CD247 had, and list some proteins which have the same functions with CD247. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PUM1,RNF10,ASCL3,SLX1B,MVK,FAM19A1,XIAP,U2AF1,PPID,TNFSF13B |
| transmembrane signaling receptor activity | VIPR1B,CLEC1B,CALCRLA,ERBB3,ADCYAP1R1A,EDAR,SLAMF1,TLR18,IL11RA,KIR2DL4 |
| protein homodimerization activity | TGFB2,MCL1,HINT2,S100A10,DMRTA1,CSF1,CIB2,CISD2,BAX,IL6ST |
| identical protein binding | TRAF6,CBY1,TP53,KRTAP10-5,SSNA1,TRIM8,NEFL,SCHIP1,DYNLT3,TYSND1 |
Interacting Protein
CD247 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD247 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD247.
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References
- Martins, M; Williams, AH; et al. Genetic association of CD247 (CD3 zeta) with SLE in a large-scale multiethnic study. GENES AND IMMUNITY 16:142-150(2015).
- Miyazawa, K; Yoda, K; et al. Influence of orally administered Lactobacillus GG on respiratory immune response in a murine model of diet-induced obesity. MICROBIOLOGY AND IMMUNOLOGY 59:99-103(2015).
