CD226

  • Official Full Name

    CD226 antigen

  • Overview

    DNAM-1 (CD226) is a ~65 kD glycoprotein expressed on cell surface of T cells, NK cells, monocytes/macrophages, platelets and megakaryocytes and a subset of B cells and a member of the immunoglobulin (Ig)-superfamily containing 2 Ig-like domains of the V-s

  • Synonyms

    CD226;CD226 antigen;platelet and T cell activation antigen 1;platelet and T-cell activation antigen 1;Pta1;DNAM1;DNAM-1;TLiSA1;BC051526

Recombinant Proteins

  • Human
  • Monkey
  • Rat
  • Mouse
  • Cynomolgus
  • Rhesus macaque
  • Zebrafish
  • Macaca mulatta
  • HEK293
  • Human Cells
  • Insect Cells
  • CHO
  • Wheat Germ
  • E.coli
  • Mammalian Cells
  • Avi&Fc
  • Fc
  • His
  • Fc&His
  • Avi&His
  • GST
  • His&T7
  • Non
  • hIgG4
  • Flag
  • DDK&Myc
  • Avi&Fc&His
  • His&mFc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CD226-636H Active Recombinant Human CD226 Protein, Fc & Avi-tagged, Biotinylated HEK293 Human Avi&Fc Glu 19 - Asn 247
CD226-248CAF488 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Monkey Fc 19-247 a.a.
CD226-248CAF555 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Monkey Fc 19-247 a.a.
CD226-248CAF647 Active Recombinant Monkey CD226 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Monkey Fc 19-247 a.a.
CD226-248CF Active Recombinant Monkey CD226 Protein, Fc-tagged, FITC conjugated HEK293 Monkey Fc 19-247 a.a.
Cd226-1105R Recombinant Rat Cd226 protein(Met1-Ile265), His-tagged HEK293 Rat His 1-265 a.a.
CD226-2190H Recombinant Human CD226, His tagged Human Cells Human His 1-247 a.a.
Cd226-2274M Active Recombinant Mouse Cd226 protein, His-tagged HEK293 Mouse His 1-254 a.a.
CD226-634H Recombinant Human CD226, Fc-His tagged Human Cells Human Fc&His 1-247 a.a.
CD226-635H Recombinant Human CD226 protein, Fc-tagged HEK293 Human Fc 229
Cd226-635M Recombinant Mouse Cd226, Fc-His tagged Human Cells Mouse Fc&His 1-254 a.a.
Cd226-8794R Active Recombinant Rat Cd226 protein, hFc-tagged HEK293 Rat Fc Met1-Ile265
CD226-01H Recombinant Human CD226 Protein, hIgG-His-Tagged Insect Cells Human Fc&His 471aa
Cd226-1105RAF488 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Rat His 245
Cd226-1105RAF555 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Rat His 245
Cd226-1105RAF647 Recombinant Rat Cd226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Rat His 245
Cd226-1105RF Recombinant Rat Cd226 Protein, His-tagged, FITC conjugated HEK293 Rat His 245
CD226-2190HAF488 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 240
CD226-2190HAF555 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 240
CD226-2190HAF647 Recombinant Human CD226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Human His 240
CD226-2190HF Recombinant Human CD226 Protein, His-tagged, FITC conjugated HEK293 Human His 240
Cd226-2274MAF488 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His 247
Cd226-2274MAF555 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His 247
Cd226-2274MAF647 Recombinant Mouse Cd226 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His 247
Cd226-2274MF Recombinant Mouse Cd226 Protein, His-tagged, FITC conjugated HEK293 Mouse His 247
CD226-634HAF488 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc&His 477
CD226-634HAF555 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc&His 477
CD226-634HAF647 Recombinant Human CD226 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc&His 477
CD226-634HF Recombinant Human CD226 Protein, Fc/His-tagged, FITC conjugated HEK293 Human Fc&His 477
CD226-635HAF488 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 229
CD226-635HAF555 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 229
CD226-635HAF647 Recombinant Human CD226 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 229
CD226-635HF Recombinant Human CD226 Protein, hFc-tagged, FITC conjugated HEK293 Human Fc 229
Cd226-635MAF488 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse Fc&His 484
Cd226-635MAF555 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse Fc&His 484
Cd226-635MAF647 Recombinant Mouse Cd226 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse Fc&His 484
Cd226-635MF Recombinant Mouse Cd226 Protein, Fc/His-tagged, FITC conjugated HEK293 Mouse Fc&His 484
Cd226-8794RAF488 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Rat Fc 475
Cd226-8794RAF555 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Rat Fc 475
Cd226-8794RAF647 Recombinant Rat Cd226 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Rat Fc 475
Cd226-8794RF Recombinant Rat Cd226 Protein, Fc-tagged, FITC conjugated HEK293 Rat Fc 475
CD226-248C Active Recombinant Cynomolgus CD226 protein, Fc-tagged HEK293 Cynomolgus Fc 19-247 a.a.
CD226-051H Active Recombinant Human CD226 protein, His/Avi-tagged, Biotinylated HEK293 Human Avi&His Glu19-Asn247
CD226-052H Active Recombinant Human CD226 protein, Fc/Avi-tagged, CHO Human Avi&Fc Glu19-Asn247
CD226-635HP Active Recombinant Human CD226 protein, Fc-tagged, R-PE labeled HEK293 Human Fc Met1-Asn247
CD226-6744H Recombinant Human CD226 protein, hFc-tagged HEK293 Human Fc Glu19-Asn247
CD226-0750H Recombinant Human CD226 Protein, GST-Tagged Wheat Germ Human GST
CD226-139H Recombinant Human CD226 protein, T7/His-tagged E.coli Human His&T7 19-254 a.a.
CD226-1603H Recombinant Human CD226 Molecule Mammalian Cells Human Non
CD226-1607R Recombinant Rhesus Monkey CD226 Protein HEK293 Rhesus macaque Non 19-254 a.a.
CD226-1608R Recombinant Rhesus Monkey CD226 Protein, hIgG1-tagged HEK293 Rhesus macaque Fc 19-254 a.a.
CD226-1609R Recombinant Rhesus Monkey CD226 Protein, hIgG4-tagged HEK293 Rhesus macaque hIgG4 19-254 a.a.
CD226-229H Recombinant Human CD226 protein, His-tagged HEK293 Human His Glu19-Asn247
CD226-5128Z Recombinant Zebrafish CD226 Mammalian Cells Zebrafish His
CD226-7254H Recombinant Human CD226, His-tagged E.coli Human His 19-254aa
CD226-729R Recombinant Rhesus monkey CD226 Protein, His-tagged Mammalian Cells Rhesus macaque His
CD226-1167CCL Recombinant Cynomolgus CD226 cell lysate Human Cells Cynomolgus Non
CD226-1173RCL Recombinant Rat CD226 cell lysate Human Cells Rat Non
CD226-2645HCL Recombinant Human CD226 cell lysate Human Cells Human Non
CD226-2800MCL Recombinant Mouse CD226 cell lysate Human Cells Mouse Non
CD226-1273HFL Recombinant Full Length Human CD226 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
CD226-1274H Active Recombinant Human CD226 protein, hFc&His-tagged HEK293 Human Fc&His Glu19-Asn247
CD226-151H Recombinant Human CD226 Protein, His-tagged Human Cells Human His
Cd226-2056M Recombinant Mouse Cd226 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
CD226-2190HB Recombinant Human CD226 protein, His-tagged, Biotinylated HEK293 Human His 1-247 a.a.
CD226-220H Recombinant Human CD226 Protein, C-His-tagged E.coli Human His
CD226-23H Recombinant Human CD226 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Human Fc&His Glu19-Asn247
CD226-248CA Recombinant Cynomolgus CD226 protein, Fc-tagged, APC labeled HEK293 Cynomolgus Fc
CD226-248CP Recombinant Cynomolgus CD226 protein, Fc-tagged, R-PE labeled HEK293 Cynomolgus Fc
CD226-248HG Active GMP Recombinant Human CD226 protein HEK293 Human DNA sequence encoding Human DNAM-1(NCBI Reference Sequence: NP_006557.2) was expressed with His tag at the C-terminal.
CD226-3056H Recombinant Human CD226 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
CD226-318C Recombinant Cynomolgus CD226 protein, His-tagged HEK293 Cynomolgus His Glu19-Phe252
CD226-3924H Recombinant Human CD226 Protein (Met1-Asn247), C-His tagged Mammalian Cells Human His Met1-Asn247
CD226-395H Recombinant Human CD226 Protein (Met1-Asn247), His-Fc-tagged, Biotinylated HEK293 Human Fc&His Met1-Asn247
CD226-4374H Recombinant Human CD226 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
CD226-4374H-B Recombinant Human CD226 Protein Pre-coupled Magnetic Beads HEK293 Human
CD226-5428H Recombinant Human CD226 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
CD226-555R Recombinant Rhesus Macaque CD226 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CD226-555R-B Recombinant Rhesus Macaque CD226 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
Cd226-5756M Recombinant Mouse Cd226 Protein (Glu19-Pro254), C-His tagged Mammalian Cells Mouse His Glu19-Pro254
CD226-578H Recombinant Human CD226 protein, His-Avi-tagged HEK293 Human Avi&His Glu19-Asn247
CD226-583H Recombinant Human CD226 Protein (Glu19-Asn247), C-mFc and 6×His-tagged HEK293 Human His&mFc Glu19-Asn247
CD226-634HA Recombinant Human CD226 protein, Fc-His-tagged, APC labeled HEK293 Human Fc&His
CD226-634HP Recombinant Human CD226 protein, Fc-His-tagged, R-PE labeled HEK293 Human Fc&His
CD226-635HA Recombinant Human CD226 protein, Fc-tagged, APC labeled HEK293 Human Fc
Cd226-635MA Recombinant Mouse Cd226 protein, Fc-His-tagged, APC labeled HEK293 Mouse Fc&His
Cd226-635MP Recombinant Mouse Cd226 protein, Fc-His-tagged, R-PE labeled HEK293 Mouse Fc&His
CD226-658H Recombinant Human CD226 Protein HEK293 Human 336
CD226-659H Recombinant Human CD226 Protein, Fc-tagged HEK293 Human Fc 336
Cd226-8794RA Recombinant Rat Cd226 protein, Fc-tagged, APC labeled HEK293 Rat Fc
Cd226-8794RP Recombinant Rat Cd226 protein, Fc-tagged, R-PE labeled HEK293 Rat Fc
RFL4722MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) Cd226 Antigen(Cd226) Protein, His-Tagged E.coli Macaca mulatta His Full L. Full Length of Mature Protein (19-336)

    Involved Pathway

    CD226 involved in several pathways and played different roles in them. We selected most pathways CD226 participated on our site, such as Adaptive Immune System,Cell adhesion molecules (CAMs),Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD226 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) CLDN15A,ITGB2L,PVRL1,PVRL3B,CLDN11,CD8B1,CLDN2,ITGAM,CLDNC,CNTN2
    Adaptive Immune System CLTA,CD200R3,CREB1B,CYBA,KIF2A,SPSB1,KLRB1A,PTBP3,WSB1,LILRB1
    Immune System ARIH1,IFIT14,KLHL21,WIPF2,RCA2.1,GBP6,DEFB104A,CTSH,BTR16,ACTR2B
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell GM11711,ICAM4,CD300LF,TREM1,PVRL2L,AMICA1,CD200R4,TREML2,CD160,SLAMF6

    Protein Function

    CD226 has several biochemical functions, for example, cell adhesion molecule binding,integrin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD226 itself. We selected most functions CD226 had, and list some proteins which have the same functions with CD226. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding THY1,NOV,CTGF,ADAMTS13,SFRP2,FAP,ESM1,L1CAM,NF2,COL5A1
    receptor activity TLR2,NLGN2,ITGB4,NLGN3A,Siglece,RRBP1B,ICAM1,GFRA4A,PAQR3B,CNTNAP1
    protein binding TCEB2,NR1I2,USP4,CCDC43,SMU1,TAF10,HLA-A,RFPL4,ZCCHC8,SH2B2
    protein kinase binding TEX14,MAG,SHC1,CDKN2A,NEK9,GRB2,SLC12A4,Cd24a,CDKN2B,MAPT
    protein homodimerization activity AIMP1,ABAT,GPD1A,CADM1A,PON3,KCNN2,FOXP3,CREB3,KYNU,MAP3K5
    cell adhesion molecule binding CADM2,Fert2,NLGN4X,CD200,CADM1,PVR,NCR3,PVRL2L,GRIN2A,NLGN3

    Interacting Protein

    CD226 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD226 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD226.

    TIGIT;PVR;PVRL2

    Resources

    Research Area

    Cancer Drug Targets
    ITIM/ITAM Immunoreceptors and Related Molecules
    Natural Killer (NK) Cell CD Antigen
    Nectin and Nectin-like Ligand/Receptor Co-Signaling Molecules
    T Cell Migration
    Monocyte Marker CD Antigen
    Other Monocytes/Macrophages CD Antigen
    CD Antigen (T Cell Migration/Adhesion)
    Monocyte Markers
    Thymus-Dependent B Cell Activation
    Immune Checkpoints

    References

    • Johnston, RJ; Comps-Agrar, L; et al. The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8(+) T Cell Effector Function. CANCER CELL 26:923-937(2014).
    • Hou, SK; Ge, KK; et al. CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular Domain. JOURNAL OF BIOLOGICAL CHEMISTRY 289:6969-6977(2014).

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