CD151
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Official Full Name
CD151 molecule (Raph blood group) -
Overview
CD151 is a tetraspanin and is thought to aid in the creation of multi-protein complexes at the surface of cells. CD151 forms secure laminin-binding compounds in the kidney, using integrins alpha3beta1 and alpha6beta1, and in the skin, using alpha3beta1 and alpha6beta4. CD151 may also play an important role in the inner ear and may also be involved in erythropoiesis. CD151 may be an important marker for prostate cancer and the higher the level of CD151, the less likely the patient survives. Research has shown that mice lacking CD151 have a damaged re-epithelialization process and lack wound healing ability. -
Synonyms
CD151;CD151 molecule (Raph blood group);CD151 antigen , CD151 antigen (Raph blood group);CD151 antigen;PETA 3;RAPH;SFA 1;TSPAN24;tspan-24;tetraspanin-24;membrane glycoprotein SFA-1;CD151 antigen (Raph blood group);hemidesmosomal tetraspanin CD151;platelet surface glycoprotein gp27;platelet-endothelial tetraspan antigen 3;platelet-endothelial cell tetraspan antigen 3;GP27;MER2;SFA1;PETA-3
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- Macaca mulatta
- Bovine
- Mus musculus
- Chlorocebus Aethiops
- E.coli
- HEK293
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- E.coli expression system
- His
- Non
- C-His&N-Flag
- GST
- Fc
- hIgG4
- His&Fc&Avi
Involved Pathway
CD151 involved in several pathways and played different roles in them. We selected most pathways CD151 participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway,Assembly of collagen fibrils and other multimeric structures,Cell junction organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD151 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell junction organization | LIMS1,PARVB,CLDN23,CDH3,FBLIM1,ITGB1B.1,CDH9,PVRL1A,CDH2,CTNND1 |
| Assembly of collagen fibrils and other multimeric structures | LOXL2,COL4A4,COL1A1,COL2A1,CTSL1,COL8A1A,COL6A2,COL3A1,COL4A5,CTSS |
| Collagen formation | COL8A2,COL1A1,PPIB,MMP13,COL16A1,COL25A1,COL6A2,LOXL1,CRTAP,CTSB |
| Cell-Cell communication | CDH7,SIRPA,SPTBN1,F11R.2,CDH12,KIRRELB,CLDN3,JUP,KIRREL3L,DSCAML1 |
| Extracellular matrix organization | DDR1,MFAP4,TLL2,ASPN,BMP1A,COL19A1,FN1B,PCOLCE,ADAMTS8,COL4A6 |
| Alpha6-Beta4 Integrin Signaling Pathway | EGFR,SMAD3B,MST1R,PLEC,DST,EIF4EBP1,NTN1A,EIF4E,CLCA1,RTKN |
| Type I hemidesmosome assembly | COL17A1A,DST,PLECA |
Protein Function
CD151 has several biochemical functions, for example, integrin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD151 itself. We selected most functions CD151 had, and list some proteins which have the same functions with CD151. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ZSCAN1,ZNF664-FAM101A,EEF1G,DUSP7,GIP,UBA7,IL15,WBP11,TBC1D14,MPZL1 |
| integrin binding | FBN1,LAMA5,GFAP,NF2,ANGPTL3,CALR,ITGA3,ITGB1BP1,P4HB,ITGB6 |
Interacting Protein
CD151 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD151 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD151.
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References
- Tang, QH; Liu, ZY; et al. Involvement of activation of C-met signaling pathway in CD151-induced HUVECs angiogenesis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 35:35-41(2015).
- Matsumoto, N; Morine, Y; et al. Role of CD151 expression in gallbladder carcinoma. SURGERY 156:1212-1217(2014).
