CCNB1
-
Official Full Name
cyclin B1 -
Overview
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. -
Synonyms
CCNB1;cyclin B1;CCNB;G2/mitotic-specific cyclin-B1;OTTHUMP00000123478;OTTHUMP00000221981;OTTHUMP00000223023;G2/mitotic-specific cyclin B1
Recombinant Proteins
- Mouse
- Human
- Rat
- Rhesus macaque
- Zebrafish
- Yeast
- Wheat Germ
- Mammalian Cells
- E.coli
- Sf9 Cells
- Insect Cells
- In Vitro Cell Free System
- HEK293
- His
- GST
- Non
- His&MBP
- His&Myc
- Avi&Fc&His
Involved Pathway
CCNB1 involved in several pathways and played different roles in them. We selected most pathways CCNB1 participated on our site, such as FoxO signaling pathway,Cell cycle,Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCNB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | MYBL2,MND1,POLD3,TERF1,YWHAE2,AHCTF1,NEK2,ODF2,SYCP2,MPEG1.1 |
| Oocyte meiosis | IGF1RB,INS2,ANAPC4,PPP3CA,PRKACG,YWHAQB,INS1,REC8,PPP1CBL,CAMK2D2 |
| Progesterone-mediated oocyte maturation | FZR1A,PRKACBB,IGF1,CDC16,CCNB2,RPS6KA3A,HSP90AB1,INS2,CPEB4,RAF1B |
| FoxO signaling pathway | INS,HOMER3,PRKAG2,MAPK12B,RAG2,PDPK1B,PTENB,HOMER1B,PIK3R5,PRKAG3 |
| p signaling pathway | SESN2,IGF1,TP53AIP1,CCNB3,CCND2,CASP3A,BAI1,RRM2B,BAX,BID |
Protein Function
CCNB1 has several biochemical functions, for example, histone kinase activity,patched binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCNB1 itself. We selected most functions CCNB1 had, and list some proteins which have the same functions with CCNB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| patched binding | CAV1,SETD6,DHH,PTCH1,IHH,SMO,BBS1,Shh |
| protein kinase binding | KIF13B,SHC3,SKI,SKAP1,CDC25A,CHRNA7,CDKN2D,PRKAG3,KIF20A,CENPJ |
| histone kinase activity | BAZ1B,CDK1 |
| protein binding | PLEKHB1,MAT2A,NAMPT,L3MBTL1,WNT11,S100A16,RAB17,SCAF8,CDK15,BBS5 |
Interacting Protein
CCNB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCNB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCNB1.
CDK1;CDK2;PKMYT1
Resources
Research Area
Tumor AntigensG2/M (DNA Damage) Checkpoints
Metaphase (Mitotic Spindle) Checkpoints
Cyclins
Related Services
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References
