CAST
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Official Full Name
calpastatin -
Overview
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] -
Synonyms
CAST;calpastatin;BS-17;calpain inhibitor;sperm BS-17 component
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Yeast
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CAST-10743H | Recombinant Human CAST, GST-tagged | E.coli | Human | GST | N-term-350a.a. | |
| CAST-0441H | Recombinant Human CAST Protein, GST-Tagged | Wheat Germ | Human | GST |
|
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| CAST-1149R | Recombinant Rat CAST Protein | Mammalian Cell | Rat | His |
|
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| CAST-27210TH | Recombinant Human CAST | Wheat Germ | Human | Non | 88 amino acids |
|
| CAST-27403TH | Recombinant Human CAST | Wheat Germ | Human | Non | 686 amino acids |
|
| CAST-3882C | Recombinant Chicken CAST | Mammalian Cell | Chicken | His |
|
|
| CAST-7075Z | Recombinant Zebrafish CAST | Mammalian Cell | Zebrafish | His |
|
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| CAST-7824HCL | Recombinant Human CAST 293 Cell Lysate | HEK293 | Human | Non |
|
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| CAST-1350H | Recombinant Human CAST Protein (1-667 aa), His-tagged | Yeast | Human | His | 1-667 aa |
|
| CAST-1363H | Recombinant Human CAST Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| CAST-1434H | Recombinant Human CAST Protein (Ala446-Lys636), N-His tagged | E.coli | Human | His | Ala446-Lys636 |
|
| CAST-2638H | Recombinant Human CAST protein, His-tagged | E.coli | Human | His | 1-667aa |
|
| CAST-2751HF | Recombinant Full Length Human CAST Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 686 amino acids |
|
| CAST-50HF | Recombinant Full Length Human CAST Protein | In Vitro Cell Free System | Human | Full L. 686 amino acids |
|
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| CAST-628H | Recombinant Human CAST Protein, His&GST-tagged | E.coli | Human | His&GST | Ala446-Lys636 |
|
| Cast-776M | Recombinant Mouse Cast Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CAST-807R | Recombinant Rat CAST Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| CAST-807R-B | Recombinant Rat CAST Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
CAST involved in several pathways and played different roles in them. We selected most pathways CAST participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CAST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CAST has several biochemical functions, for example, calcium-dependent cysteine-type endopeptidase inhibitor activity,endopeptidase inhibitor activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAST itself. We selected most functions CAST had, and list some proteins which have the same functions with CAST. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protease binding | FADD,RYR1,ITGAV,TTN,SERPINA1D,INS1,TYSND1,STIM1,SERPINA1E,CD70 |
| poly(A) RNA binding | POU5F1,CPEB4,YARS2,ZC3H18,NARG1,DDX23,SAFB,MRPL41,RSL24D1,DHX15 |
| endopeptidase inhibitor activity | Cstb,SERPINA1D,CST14B.1,SLPI,SPINK2,RECK,TFPI,SERPINA1A,PZP,SERPINA1E |
| protein binding | ACY3,KAL1,H2-AA,FBXL14,C4orf46,MTAP,SUSD2,CAND1,GDNF,ECT2 |
Interacting Protein
CAST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAST here. Most of them are supplied by our site. Hope this information will be useful for your research of CAST.
q9z305_cavpo;ABL1;FYN;SRC;NCK1;CAPN2;PLCG1;PIK3R1;CRK;GRB2;Kif13b;CAPN1;BAG6
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References
- Mahmoud, GA; Zayed, HS; et al. Renal outcomes among Egyptian lupus nephritis patients: a retrospective analysis of 135 cases from a single centre. LUPUS 24:331-338(2015).
- Langdon, BB; Mirhossaini, RB; et al. Single-Molecule Resolution of Protein Dynamics on Polymeric Membrane Surfaces: The Roles of Spatial and Population Heterogeneity. ACS APPLIED MATERIALS & INTERFACES 7:3607-3617(2015).
