CA1
-
Official Full Name
carbonic anhydrase I -
Overview
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. -
Synonyms
CA1;carbonic anhydrase I;carbonic anhydrase 1;Car1;JW0122;CA 1;CA I;CA-I;CAB;CAH1_HUMAN;CAI;CAN;Car 1;Carbonate dehydratase I;Carbonic anhydrase B;Carbonic dehydratase;ECK0125;yadF;OTTHUMP00000227973;OTTHUMP00000227974;OTTHUMP00000227976;OTTHUMP00000227977;OTTHUMP00000227978;OTTHUMP00000227979;OTTHUMP00000227981;Car-1;AW555628
Recombinant Proteins
- Human
- Rat
- Mouse
- Capsicum annuum (Bell pepper)
- E.coli
- Wheat Germ
- Human
- Mammalian Cell
- HEK293
- Yeast
- In Vitro Cell Free System
- HEK293T
- E.coli expression system
- GST
- His
- Non
- His&Strep
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
CA1 involved in several pathways and played different roles in them. We selected most pathways CA1 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | CA12,CA6,Car4,CAHZ,CA4,CAR15,CAR1,CA8,CA4A,CAR6 |
Protein Function
CA1 has several biochemical functions, for example, arylesterase activity,carbonate dehydratase activity,hydro-lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CA1 itself. We selected most functions CA1 had, and list some proteins which have the same functions with CA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| arylesterase activity | PON2,C20orf3,CAR1,APMAP,CA2,PON1,PON3,Car2 |
| hydro-lyase activity | HIBCH,CAR1,L3HYPDH |
| protein binding | C8orf33,ID2,CEP120,CDC23,CAMSAP1L1,ETNK1,HOMEZ,CAMK2D,PLOD3,B9D2 |
| carbonate dehydratase activity | CAR3,CA5,Car8,Car4,CA13,CAR6,CA7,CAHZ,CAR13,CA9 |
| zinc ion binding | PDLIM7,THRA,NR5A5,ADAMDEC1,ZCCHC16,NEURL1B,DPF3,TLL1,TRIM35-20,RNF207 |
Interacting Protein
CA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA1.
TFCP2;HSD17B7;MAPK6
Resources
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References
- Czeh, B; Varga, ZKK; et al. Chronic Stress Reduces the Number of GABAergic Interneurons in the Adult Rat Hippocampus, Dorsal-Ventral and Region-Specific Differences. HIPPOCAMPUS 25:393-405(2015).
- Wang, WC; Cheng, CF; et al. Immunohistochemical Localization of DPP10 in Rat Brain Supports the Existence of a Kv4/KChIP/DPPL Ternary Complex in Neurons. JOURNAL OF COMPARATIVE NEUROLOGY 523:608-628(2015).
