C
-
Official Full Name
chib -
Overview
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
C;chib;C22orf2, chromosome 22 open reading frame 2 , PGEA1, PKD2 interactor, golgi and endoplasmic reticulum associated 1;protein chibby homolog 1;Cby;Chibby;PIGEA 14;PIGEA14;C22orf2;Cytosolic leucine rich protein;HRIHFB2025;PKD2 interactor, Golgi and endoplasmic reticulum-associated 1;Protein Chibby;OTTHUMP00000198875;OTTHUMP00000198876;OTTHUMP00000198878;ARPP-binding protein;coiled-coil protein PIGEA-14;cytosolic leucine-rich protein;PKD2 interactor, golgi and end;arb1;PGEA1;PIGEA-14;HS508I15A
Recombinant Proteins
- HBV
- Rat
- Streptomyces phage phiC31
- JEV
- RuV
- YEV
- Mouse
- Human
- SARS
- Measles Virus
- RUBV
- DENV
- HCV
- HBV-D
- Hepatitis B virus genotype A2 subtype adw2 (strain Rutter 1979)
- Hepatitis B virus genotype A2 subtype adw2 (isolate Germany/991/1990)
- HBV-C
- Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-)
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- P.pastoris
- HEK293
- Insect Cells
- Non
- His
- GST
- SUMO
- Avi
- Fc
- Myc
- MBP
Involved Pathway
C involved in several pathways and played different roles in them. We selected most pathways C participated on our site, such as Deactivation of the beta-catenin transactivating complex,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | ARHGAP11A,RDH14,ARHGAP26,TAX1BP1B,DEPDC7,SPRY1,PTPRK,SAGB,ROR2,TNKS2 |
| Deactivation of the beta-catenin transactivating complex | CBY1,SOX32,TLE4,BCL9,CTBP1,TLE3,SOX4B,PYGO1,SOX4A,SOX7 |
| Signaling by Wnt | SOX4B,SOX13,TNKS2,RSPO1,RNF146,FAM123B,SOX9B,KREMEN2,LEO1,WNT8-2 |
| TCF dependent signaling in response to WNT | SOX7,RNF146,BCL9L,ASH2L,KREMEN1,RSPO1,SRY,LGR5,LGR6,HECW1B |
Protein Function
C has several biochemical functions, for example, beta-catenin binding,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C itself. We selected most functions C had, and list some proteins which have the same functions with C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | EPS15,DLC,SH3GL3,TRIM39,TRIM8,CLDN1,SEPHS1,ALS2CL,BAIAP2,TLR3 |
| beta-catenin binding | RORA,TRPC4,ASH2L,KDM6B,PTPRK,LEF1,PXN,DACT1,CALCOCO1,CBY1 |
Interacting Protein
C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C here. Most of them are supplied by our site. Hope this information will be useful for your research of C.
Hmga2
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References
- Yang, YR; Feng, JD; et al. Immune Responses to a Recombinant Rv0057-Rv1352 Fusion Protein of Mycobacterium tuberculosis. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:39-48(2015).
- Khosravi-Farsani, S; Amidi, F; et al. Isolation and Enrichment of Mouse Female Germ Line Stem Cells. CELL JOURNAL 16:406-415(2015).
