BTD
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Official Full Name
biotinidase -
Overview
Biotinidase functions to recycle biotin in the body by cleaving biocytin (biotin-epsilon-lysine), a normal product of carboxylase degradation, resulting in regeneration of free biotin. Biotinidase has also been shown to have biotinyl-transferase activity. Defects in the biotinidase gene cause multiple carboxylase deficiency. -
Synonyms
BTD;biotinidase;EC 3.5.1.12;Biotinase;BTD_HUMAN;OTTHUMP00000160300;OTTHUMP00000209134;OTTHUMP00000209135;OTTHUMP00000209138
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Chicken
- CHO
- Mammalian Cell
- Human Cell
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- HEK293T
- E. coli
- Mamanlian cells
- His
- His&Fc
- GST
- Myc&DDK
- Non
- His&Fc&Avi
- N-His-GST&C-Myc
- Flag
Involved Pathway
BTD involved in several pathways and played different roles in them. We selected most pathways BTD participated on our site, such as Biotin metabolism,Metabolic pathways,Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with BTD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | FBP1,ADH1,PTGES2,PTGIS,CYP2C55,ATP6V1B1,B4GALT6,PLCH1,DNMT3B,AANAT2 |
| Biotin metabolism | HLCS,OXSM |
| Vitamin digestion and absorption | SLC19A1,SCARB1,TCN2,MMACHC,CUBN,ABCC1,APOB,SLC46A1,SLC19A3,FOLH1 |
Protein Function
BTD has several biochemical functions, for example, biotinidase activity,hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. Some of the functions are cooperated with other proteins, some of the functions could acted by BTD itself. We selected most functions BTD had, and list some proteins which have the same functions with BTD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| biotinidase activity | SIRT4 |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | DPYSL4,DPYSL3,DPYSL5A,CRMP1,DPYSL5B,YDJC,DPYSL2B,DPYSL5,NAAA |
Interacting Protein
BTD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BTD here. Most of them are supplied by our site. Hope this information will be useful for your research of BTD.
KIF21B;cona_canen;CCND1;CDCA5;SIKE1
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References
- Winkens, T; Pachmann, K; et al. Circulating epithelial cells in patients with thyroid carcinoma Can they be identified in the blood?. NUKLEARMEDIZIN-NUCLEAR MEDICINE 52:7-13(2013).
- Kang, UB; Ahn, Y; et al. Differential profiling of breast cancer plasma proteome by isotope-coded affinity tagging method reveals biotinidase as a breast cancer biomarker. BMC CANCER 10:-(2010).
