BAD
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Official Full Name
BCL2-associated agonist of cell death -
Overview
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008] -
Synonyms
BAD;BCL2-associated agonist of cell death;BBC2;BCL2L8;bcl2 antagonist of cell death;bcl2-L-8;BCL2-binding protein;bcl-2-like protein 8;BCL2-binding component 6;bcl-2-binding component 6;BCL-X/BCL-2 binding protein;BCL2-antagonist of cell death protein;bcl-XL/Bcl-2-associated death promoter
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Wheat Germ
- Sf9 Cells
- E.coli
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
BAD involved in several pathways and played different roles in them. We selected most pathways BAD participated on our site, such as ErbB signaling pathway,Ras signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-small cell lung cancer | PLCG1,PIK3R3,PRKCA,PDPK1,RXRG,TGFA,PRKCB,AKT2,CCND1,PRKCG |
| Thyroid hormone signaling pathway | PRKCG,PLCB2,PLCB1,MED27,SRC,BMP4,STAT1,PRKCB,PIK3CG,PLCZ1 |
| cAMP signaling pathway | FXYD1,RRAS,ATP1B1,PTGER2,RAC2,PPP1R12A,RRAS2,VAV2,LIPE,ATP2B4 |
| cGMP-PKG signaling pathway | CREB3L2,MAP2K1,PLCB1,NPPB,NFATC4,PDE2A,ATP1B3,AKT2,CALML3,PPP3R1 |
| ErbB signaling pathway | MAP2K1,ERBB3,BRAF,ERBB3B,PIK3R2,PIK3CD,PAK2,ERBB2,MAPK9,CBLC |
| Pathways in cancer | GNB2,TRP53,GNG11,TRAF5,ARNT,TGFB3,WNT8A,SPI1,FZD5,ITGA2 |
| Acute myeloid leukemia | PIK3CG,PIM2,PIK3R3,PML,FLT3,STAT5B,ARAF,PIK3R1,CHUK,STAT5A |
| Apoptosis | PPP3CC,RELA,PRKAR1AB,PIK3CD,BCAP31,NFKBIAA,JUN,DSP,PRKACA,BNIP3LB |
| Ras signaling pathway | CALM2,PGF,MET,FOXO4,PLCG1,MLLT4,ZAP70,PLA2G12B,INS1,RRAS |
Protein Function
BAD has several biochemical functions, for example, cysteine-type endopeptidase activator activity involved in apoptotic process,lipid binding,phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BAD itself. We selected most functions BAD had, and list some proteins which have the same functions with BAD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase 2B binding | MYOZ2,AKAP5,AKAP1,SLC9A1,ATP2B4,PPP3CB,SOD1 |
| protein kinase binding | PRKCZ,RACGAP1,E2F1,GATA6,SHC1,MAP3K2,RPS6KA3,PRKACA,EMP2,LAT |
| protein binding | CECR2,DDO,LAPTM5,SLC4A1,CLDN8,TBC1D23,BLVRA,CCDC43,USP33,ZNF624 |
| protein kinase B binding | CCDC88A,BCL10,RARA,CDC37,TRAF6,ANKRD2,PDE3B,APPL1,PINK1 |
| protein heterodimerization activity | GTF2A2,VOX,SMAD1,HIST1H4C,SPNA1,AGTR1,ZHX2,ATF4,TCF3B,CEBPE |
| phospholipid binding | APOM,ANXA1,RASAL1,PACSIN1A,PRKCI,NBEAA,SERPINB1A,GLTPD1,ABCA1,LPAR3 |
| lipid binding | ACOT11,TRIP10A,CYTH2,RBP7B,PPP5C,PCYT1A,FABP9,APOEB,OSBPL6,COQ9 |
| cysteine-type endopeptidase activator activity involved in apoptotic process | NOD1,CTSC,RPS27L,CARD8,APAF1,CASP1,PYCARD,NLRP1,BCL2L13,CTSH |
Interacting Protein
BAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BAD here. Most of them are supplied by our site. Hope this information will be useful for your research of BAD.
BCL2L1;BCL2;BCL2L1
BAD Related Signal Pathway
Resources
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References
- Gamez, C; Zafra, MP; et al. Simulated gastrointestinal digestion reduces the allergic reactivity of shrimp extract proteins and tropomyosin. FOOD CHEMISTRY 173:475-481(2015).
- Omar, AAH; Haglund, C; et al. MMP-7, MMP-8, and MMP-9 in oral and cutaneous squamous cell carcinomas. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY 119:459-467(2015).
