ATP1B1
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Official Full Name
ATPase, Na+/K+ transporting, beta 1 polypeptide -
Overview
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. -
Synonyms
ATP1B1;ATPase, Na+/K+ transporting, beta 1 polypeptide;ATP1B;sodium/potassium-transporting ATPase subunit beta-1;adenosinetriphosphatase;Na, K-ATPase beta-1 polypeptide;Beta 1-subunit of Na(+),K(+)-ATPase;sodium/potassium-dependent ATPase beta-1 su
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rhesus macaque
- Chicken
- Rat
- Mus musculus
- Sus scrofa (Pig)
- Dog
- Tetronarce Californica
- Pan troglodytes
- Anguilla anguilla
- Sheep
- E.coli
- Insect Cell
- Mammalian Cell
- Human Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- E.coli expression system
- GST
- His
- Fc
- Non
- His&Fc&Avi
Involved Pathway
ATP1B1 involved in several pathways and played different roles in them. We selected most pathways ATP1B1 participated on our site, such as cGMP-PKG signaling pathway,cAMP signaling pathway,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gastric acid secretion | MYLK,ATP1A2,KCNJ1,CA2,CAMK2A,PLCB3,MYLK4,ATP1B2,ATP1A4,CALM1 |
| Pancreatic secretion | PRSS2,CLCA1,RAP1B,Slc4a2,CCKAR,KCNQ1,PLA2G12A,RAB8A,PRKCB,CLCA3 |
| Aldosterone-regulated sodium reabsorption | ATP1A4,SCNN1G,PDPK1,ATP1B4,PIK3CA,IRS1,SFN,NEDD4L,ALPHA-ENAC,HSD11B2 |
| Proximal tubule bicarbonate reclamation | ATP1A2,PCK1,GLS,GLS2,CA4,SLC9A3,FXYD2,ATP1B2,ATP1A4,ATP1B4 |
| Carbohydrate digestion and absorption | PIK3R1,PRKCB,TAS1R3,G6PC,AMY2A5,HK1,ATP1B3,PIK3R2,AMY2A2,AMY2A |
| Mineral absorption | STEAP2,HMOX1,CYBRD1,ATP1A1,SLC11A1,ATP1B3,FTH1,STEAP1,SLC26A3,TF |
| Endocrine and other factor-regulated calcium reabsorption | BDKRB2,TRPV5,KLK1B24,PRKCA,ATP1A3,VDR,KLK1B3,PRKACB,PRKCB,KLK1B1 |
| Bile secretion | ADCY7,CYP3A4,ADCY9,NR0B2,AQP9,SLC4A4,Car2,ABCG2,ABCB1,PRKACG |
| Protein digestion and absorption | COL13A1,SLC3A1,SLC9A3,MEP1B,CPB1,SLC8A2,CPA2,CPB2,SLC8A1,PGA4 |
Protein Function
ATP1B1 has several biochemical functions, for example, contributes_to ATP binding,ATPase activator activity,contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1B1 itself. We selected most functions ATP1B1 had, and list some proteins which have the same functions with ATP1B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TTK,SUN1,LRP4,PDCD2,UFL1,ZBED4,CHORDC1,RGP1,ADAMTSL4,LRRC7 |
| ATPase activator activity | DNAJC19,TOR1AIP1,DNAJB6,ATP1B2,AHSA1,ATP1B3,MYBPC3,DNAJC24,TOR1AIP2,DNAJB1 |
| protein C-terminus binding | CEP120,TRP53,PCGF1,FOXN3,SREBF2,DLG1,IFT52,SP1,SLC9A3R2,AXIN1 |
| contributes_to sodium:potassium-exchanging ATPase activity | ATP1A1,ATP1A2,ATP1B3,ATP1B2 |
| contributes_to drug binding | ATP1A2,PGGT1B |
| contributes_to ATPase activity | ATP1A2,ATP5D,ABCA7,RFC3,RUVBL2,ATP5A1,ATP6V1H,ABCG8,ATP5H,PPP2R4 |
| contributes_to potassium ion binding | ATP1A2 |
| ATPase binding | EZR,ATP6V1G1,SDF2L1,TCIRG1,FXYD1,SLN,PDE4D,ESR1,FAM119A,PEX19 |
| MHC class II protein complex binding | PKM,HLA-DOB,CD81,CD74,YWHAE,HLA-DRB1,HLA-DRA,HLA-DMB,HLA-DMA,HLA-DOA |
Interacting Protein
ATP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1B1.
SLC4A1;MLC1;NR3C1;SMAD2;DDAH2;CRIP2;PSME1;EZH2;RIF1;TRMT2A;KMT2B;ouabain
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References
- Willmsa, K; Shoemaker, CB; et al. Cloning and expression of a Na+, K+-ATPase alpha-subunit from Taenia solium (TNaK1 alpha). MOLECULAR AND BIOCHEMICAL PARASITOLOGY 138:79-82(2004).
- Therien, AG; Goldshleger, R; et al. Tissue-specific distribution and modulatory role of the gamma subunit of the Na,K-ATPase. JOURNAL OF BIOLOGICAL CHEMISTRY 272:32628-32634(1997).
