AQP4
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Official Full Name
aquaporin 4 -
Overview
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. -
Synonyms
AQP4;aquaporin 4;aquaporin-4;MIWC;WCH4;aquaporin type4;mercurial-insensitive water channel;HMIWC2;MGC22454
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Chicken
- Mouse
- Rhesus macaque
- Mus musculus
- Bovine
- Milnesium tardigradum (Water bear) (Tardigrade)
- Dipodomys merriami (Merriam's kangaroo rat)
- Notomys alexis (Spinifex hopping mouse)
- E.coli
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- Yeast
- HEK293
- In Vitro Cell Free System
- His
- GST
- SUMO
- Non
- GFP
- Avi
- Fc
- Myc
Involved Pathway
AQP4 involved in several pathways and played different roles in them. We selected most pathways AQP4 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AQP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | ABCG2,ABCB1,CFTR,SLC10A2,SLCO1B3,ABCG8,AQP1,ATP1B3,SLC5A1,HMGCR |
Protein Function
AQP4 has several biochemical functions, for example, glycerol channel activity,water channel activity,water transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AQP4 itself. We selected most functions AQP4 had, and list some proteins which have the same functions with AQP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| water transmembrane transporter activity | AQP3B,AQP1,MIPB,AQP8A.1,MIPA,AQP3A,AQP8B,AQP10A,AQP10B,SLC14A1 |
| water channel activity | AQP9,AQP8A.2,AQP8B,MIP,MIPA,AQP2,AQP3,AQP1A.2,AQP3B,AQP9B |
| glycerol channel activity | AQP8,AQP8A.2,AQP7,AQP9B,AQP1A.2,AQP8A.1,AQP2,MIPA,AQP10B,AQP1A.1 |
Interacting Protein
AQP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AQP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of AQP4.
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References
- Aboulenein-Djamshidian, F; Hoeftberger, R; et al. Reduction in Serum Aquaporin-4 Antibody Titers During Development of a Tumor-Like Brain Lesion in a Patient With Neuromyelitis Optica: A Serum Antibody-Consuming Effect?. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 74:194-197(2015).
- Chang, KH; Ro, LS; et al. Biomarkers for neuromyelitis optica. CLINICA CHIMICA ACTA 440:64-71(2015).
