APOB
-
Official Full Name
apolipoprotein B -
Overview
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008] -
Synonyms
APOB;apolipoprotein B;FLDB;LDLCQ4;apolipoprotein B-100;apoB-48;apoB-100;apo B-100;mutant Apo B 100;apolipoprotein B48;apolipoprotein B (including Ag(x) antigen)
Recombinant Proteins
- Human
- Mouse
- Pig
- Rat
- Chicken
- Pan paniscus
- Cattle
- Wheat Germ
- Mammalian Cell
- E.coli
- Yeast
- Human Tissue
- Natural extract
- Human plasma
- Human Plasma
- HEK293
- GST
- His
- His&GST
- His&T7
- Non
- His&SUMO
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| APOB-128H | Recombinant Human APOB protein, GST-tagged | Wheat Germ | Human | GST | 28-127 a.a. |
|
| APOB-1784M | Recombinant Mouse APOB Protein | Mammalian Cell | Mouse | His |
|
|
| APOB-2095P | Recombinant Pig APOB protein, His & GST-tagged | E.coli | Pig | His&GST | His331~Glu511 |
|
| Apob-2096R | Recombinant Rat Apob protein, His & T7-tagged | E.coli | Rat | His&T7 | Phe3329~Arg3494 |
|
| APOB-27149TH | Recombinant Human APOB, His-tagged | E.coli | Human | His | 1406-1606 a.a. |
|
| APOB-3425C | Recombinant Chicken APOB | Mammalian Cell | Chicken | His |
|
|
| Apob-493M | Recombinant Mouse Apob protein, His-tagged | E.coli | Mouse | His | His3360~Arg3526 |
|
| APOB-03P | Recombinant Pan paniscus APOB Protein | E.coli | Pan paniscus |
|
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| APOB-0604H | Recombinant Human APOB Protein (Ile3374-Val3600), N-His-tagged | E.coli | Human | His | Ile3374-Val3600 |
|
| APOB-0605H | Recombinant Human APOB Protein, Tag Free | E.coli | Human | Non |
|
|
| APOB-1813H | Recombinant Human APOB Protein (28-127 aa), His-tagged | Yeast | Human | His | 28-127 aa |
|
| APOB-1H | Native Human Apolipoprotein B | Human Tissue | Human | Non |
|
|
| APOB-216H | Native Human APOB Protein | Natural extract | Human |
|
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| Apob-217R | Recombinant Rat Apob Protein, His-tagged | E.coli | Rat | His | Asp29-Val293 |
|
| APOB-218C | Recombinant Cattle APOB Protein, His-tagged | E.coli | Cattle | His | Thr4331-Phe4567 |
|
| APOB-219H | Recombinant Human APOB Protein, His-tagged | E.coli | Human | His | His3365-Glu3548 |
|
| APOB-2534H | Recombinant Human APOB protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 28-127aa |
|
| APOB-2535H | Recombinant Human APOB protein, His-tagged | E.coli | Human | His | 28-127aa |
|
| APOB-26875TH | Native Human APOB | Human | Non | Full L. |
|
|
| ApoB-3556H | Native Human ApoB | Human plasma | Human | Non |
|
|
| Apob-494M | Recombinant Mouse Apob Protein, His-SUMO-tagged | E.coli | Mouse | His&SUMO | Leu32~Met306 |
|
| APOB-613H | Native Human Apolipoprotein B (including Ag(x) antigen) | Human Plasma | Human | Non |
|
|
| APOB-630M | Recombinant Mouse APOB Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| APOB-630M-B | Recombinant Mouse APOB Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
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| APOB-8037H | Native Human Plasma APOB | Human Plasma | Human | Non |
|
Involved Pathway
APOB involved in several pathways and played different roles in them. We selected most pathways APOB participated on our site, such as Fat digestion and absorption,Vitamin digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin digestion and absorption | SLC52A3,SLC19A2,RBP2,LMBRD1,FOLH1,SLC23A1,SLC19A1,SLC19A3,MMACHC,LRAT |
| Fat digestion and absorption | PPAP2A,PLA2G2A,PLA2G3,CD36,FABP2,PNLIP,ABCA1,PPAP2C,ACAT2,SLC27A4 |
Protein Function
APOB has several biochemical functions, for example, cholesterol transporter activity,heparin binding,lipase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOB itself. We selected most functions APOB had, and list some proteins which have the same functions with APOB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipase binding | LRPAP1,APOA5,PLIN5,GPIHBP1,FAF2 |
| phospholipid binding | APOC3,LPAR3,APOA1,SMURF1,RASAL1,ABCA1,GRK5,DGKA,OTC,AGAP1 |
| low-density lipoprotein particle receptor binding | LRPAP1,MMP13,DNAJA1,AP2M1,SYT1,LRP2,DKK1,LDLRAP1,APOE,MESDC2 |
| cholesterol transporter activity | APOA4,APOA4B.1,ABCA1,APOA4B.2,ABCA13,APOA1,APOA5,ABCG4B,CETP,ABCA7 |
| protein binding | DKK1B,SNAPIN,HPCAL1,SPRR1A,WNT3,DYNC1H1,TRIM33,CALM2,TMEM19,CST9L |
| heparin binding | SLIT2,BMP7,FGFR1,FGF9,PRELP,THBS3,SLIT1,WISP3,UBE4A,PCOLCE |
Interacting Protein
APOB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOB here. Most of them are supplied by our site. Hope this information will be useful for your research of APOB.
LDLR;p29991-pro_0000037946;p27958-pro_0000037576;YBX1;p29991-pro_0000037941;AKT2;SMAD3;BNLF1;BNRF1;PRDX4;ARFGAP1;q99ib8-pro_0000045592;q9wmx2-pro_0000037550;midostaurin;RAD21
Resources
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References
- Brautbar, A; Leary, E; et al. Genetics of Familial Hypercholesterolemia. CURRENT ATHEROSCLEROSIS REPORTS 17:-(2015).
- Verhoeven, V; Van der Auwera, A; et al. Can red yeast rice and olive extract improve lipid profile and cardiovascular risk in metabolic syndrome?: a double blind, placebo controlled randomized trial. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE 15:-(2015).
