ANGPT4
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Official Full Name
angiopoietin 4 -
Overview
Angiopoietins 3 (Ang-3); is a secretory protein1 and a ligands of Tie-2 receptor tyrosine kinase.2 Ang3 is most abundant in adrenal gland, placenta, thyroid gland, heart and small intestine.1 It inhibits endothelial cell proliferation and survival and blo -
Synonyms
ANGPT4;angiopoietin 4;angiopoietin-4;ANG-3;ANG-4;angiopoietin 3;angiopoietin-3;Ang3;Agpt4;MGC156453
Recombinant Proteins
- Human
- Mouse
- Rat
- Mammalian cells
- HEK293
- Wheat Germ
- E.coli
- Human Cell
- Non
- Fc
- His
- GST
- His&GST
- His&T7
- His&Fc&Avi
Involved Pathway
ANGPT4 involved in several pathways and played different roles in them. We selected most pathways ANGPT4 participated on our site, such as Ras signaling pathway,Rap signaling pathway,HIF- signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF- signaling pathway | CAMK2G,Il6ra,TIMP1,HIF1A,INS2,TFRC,IL6R,MKNK1,PRKCA,PLCG1 |
| PIK-Akt signaling pathway | ITGAV,RAF1,GNG10,COL6A6,TCL1,CCND2,YWHAG,PPP2R1B,TLR2,GNG4 |
| Rap signaling pathway | ACTG1,PLCB1,PARD6A,PGF,FGF18,MAPK3,IGF1R,FGF13,ARAP3,FPR1 |
| Ras signaling pathway | MAPK1,Pdgfa&Pdgfb,RASA1,FGF17,GNB1,GNG3,FLT1,PLA2G2F,IGF1R,SHC1 |
Protein Function
ANGPT4 has several biochemical functions, for example, receptor tyrosine kinase binding,transmembrane receptor protein tyrosine kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPT4 itself. We selected most functions ANGPT4 had, and list some proteins which have the same functions with ANGPT4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor tyrosine kinase binding | HYAL2,ANXA5,SHC3,LRP4,FIZ1,NRG1,PIK3R2,NRG3,ANGPT2A,ANGPT2 |
| transmembrane receptor protein tyrosine kinase activator activity | EFNA5,NRG1,NRG3,GREM1,EGF |
Interacting Protein
ANGPT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPT4.
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References
- Li, L; Chong, HC; et al. Angiopoietin-like 4 Increases Pulmonary Tissue Leakiness and Damage during Influenza Pneumonia. CELL REPORTS 10:654-663(2015).
- Kaneko, K; Tsuji, S; et al. Pathogenesis of childhood idiopathic nephrotic syndrome: a paradigm shift from T-cells to podocytes. WORLD JOURNAL OF PEDIATRICS 11:21-28(2015).
