ALG2
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Official Full Name
asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) -
Overview
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. -
Synonyms
ALG2;asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae);asparagine linked glycosylation 2 homolog (yeast, alpha 1,3 mannosyltransferase);alpha-1,3/1,6-mannosyltransferase ALG2;CDGIi;FLJ14511;hALPG2;NET38;OTTHUMP00000123474;3-mannosyltransferase ALG2;ALG2_HUMAN;Alpha 1,3 mannosyltransferase ALG2;Alpha-1;Asparagine linked glycosylation protein 2;Asparagine-linked glycosylation protein 2 homolog;GDP Man:Man(1)GlcNAc(2) PP dolichol mannosyltransferase;GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase;OTTHUMP00000021785;RP11-13B9.1;homolog of yeast ALG2;alpha-1,3-mannosyltransferase ALG2;GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase;GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase;asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase);asparagine-linked glycosylation 2 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase)
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- Ashbya gossypii
- Yarrowia lipolytica
- Rhizomucor pusillus
- Candida Glabrata
- Mus musculus
- Kluyveromyces lactis
- Schizosaccharomyces pombe
- Debaryomyces hansenii
- S.cerevisiae
- Dictyostelium Discoideum
- Candida albicans
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- HEK293T
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- N-GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ALG2 involved in several pathways and played different roles in them. We selected most pathways ALG2 participated on our site, such as Asparagine N-linked glycosylation,Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | ADAMTS5,ST8SIA3,EIF2B1,MBOAT4,PHC1,TMED10,EXOSC8,CHCHD4,PFDN2,MUC1 |
| Asparagine N-linked glycosylation | DAD1,MPDU1B,YKT6,MAN1B1,TRAPPC6BL,SEC22C,ALG10B,MGAT4A,CSNK1D,NSFB |
| N-Glycan biosynthesis | ALG3,ALG11,ALG8,MGAT4A,ALG10B,ST6GAL1,ALG6,MAN1B1,STT3A,RPN1 |
| Post-translational protein modification | MUC12,SSPO,MUC4,TFG,DPH1,MGAT4B,TRAPPC6A,TMED10,GCNT3,B3GNT8 |
| Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | DPAGT1,ST8SIA3,MPDU1B,ST6GALNAC2,ALG14,ST3GAL3A,ALG10B,MPDU1A,MPDU1,GNE |
| Metabolic pathways | ALG11,GLS2,QPRT,IMPA1,CYP2B6,LPIN1,ACSL3,PIPOX,PCCA,ACSL4A |
Protein Function
ALG2 has several biochemical functions, for example, GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity,alpha-1,3-mannosyltransferase activity,calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG2 itself. We selected most functions ALG2 had, and list some proteins which have the same functions with ALG2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | HDAC1,DCTN4,PDLIM5,RPS21,RELA,GTF2H2,PEX19,NIPBL,EIF5A,ARF6 |
| alpha-1,3-mannosyltransferase activity | GALNTL4,B3GNT8,PIGB,4931440L10Rik,POC1BL,GALNT18A,DPY19L4,GTDC2,B3GNTL1,ALG3 |
| protein binding | FAM49B,RAB33B,POU3F3,SCOC,SSH1,SMARCD1,CDK20,TBC1D16,THG1L,FAM109B |
| protein heterodimerization activity | SOX17,PRPH,ABTB2,HIST1H2BN,IKBKB,GTF2A1,HEYL,PAFAH1B3,NPM1,CHRNA3 |
| calcium-dependent protein binding | TNNI3,CALM3,CALM1,CD209A,C9orf9,STMN2,STX2,CLEC4M,SEC31A,MASP2 |
Interacting Protein
ALG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG2.
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