AGPAT3
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Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 3 -
Overview
The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
AGPAT3;1-acylglycerol-3-phosphate O-acyltransferase 3;1-acyl-sn-glycerol-3-phosphate acyltransferase gamma;LPAAT gamma;1-AGP acyltransferase 3;1-AGPAT 3;acyltransferase gamma;LPAAT-gamma;Lysophosphatidic acid acyltransferase gamma;UNQ759/PRO1490;lysophosphatidic acid acyltransferase-gamma1;LPAAT-GAMMA1
Recombinant Proteins
- Human
- Zebrafish
- Mus musculus
- Pongo Abelii
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
Involved Pathway
AGPAT3 involved in several pathways and played different roles in them. We selected most pathways AGPAT3 participated on our site, such as Glycerolipid metabolism,Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGPAT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | GALK1,ACY1,NADK,SQLE,GUK1,IMPDH1,PAPSS2,IDH2,PNLIPRP3,QDPR |
| Phospholipase D signaling pathway | GRM6,GRM8,DGKE,AGTR1B,PPAP2B,LPAR3,HRAS,IL-8,CXCR2,PIK3R2 |
| Glycerolipid metabolism | AKR1A1,AGPAT1,DGKE,AKR1A1A,PPAP2D,AKR1B1L,AGPAT9L,AGPAT2,PNLIPRP3,AGPAT9 |
| Glycerophospholipid metabolism | DGKQ,GPD1A,PLD1,PPAP2C,GPD1L,TAZ,PPAP2B,PLA2G2F,CHKA,PLD4 |
Protein Function
AGPAT3 has several biochemical functions, for example, 1-acylglycerol-3-phosphate O-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AGPAT3 itself. We selected most functions AGPAT3 had, and list some proteins which have the same functions with AGPAT3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase activity | LCLAT1,AGPAT4,LYCAT,AGPAT5,AGPAT2,ABHD5,AGPAT1,AGPAT9L,AGPAT9,LPCAT2 |
Interacting Protein
AGPAT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGPAT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGPAT3.
CREB3;valS
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References
- Nafikov, RA; Schoonmaker, JP; et al. Polymorphisms in lipogenic genes and milk fatty acid composition in Holstein dairy cattle. GENOMICS 104:572-581(2014).
- Bunel, A; Jorssen, EP; et al. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential. THERIOGENOLOGY 83:228-237(2015).
