ADAMTS18

  • Official Full Name

    ADAM metallopeptidase with thrombospondin type 1 motif, 18

  • Overview

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.

  • Synonyms

    ADAMTS18;ADAM metallopeptidase with thrombospondin type 1 motif, 18;a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 , ADAMTS21;A disintegrin and metalloproteinase with thrombospondin motifs 18;ADAMTS 18;ADAMTS21;EC 3.4.24.;ADAM-TS18;ADAMTS-18;ADAM-TS 18;disintegrin and metalloprotease-like protein;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21;KNO2

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • E. coli
  • GST
  • His
  • Non
  • His&Fc&Avi
  • N-His-GST&C-Myc
  • N-GST
  • N-His
Cat.# Product name Source (Host) Species Tag Protein Length Price
ADAMTS18-26H Recombinant Human ADAMTS18 protein, GST-tagged E.coli Human GST 892-1060 a.a.
ADAMTS18-1315M Recombinant Mouse ADAMTS18 Protein Mammalian Cell Mouse His
ADAMTS18-302H Recombinant Human ADAMTS18 Protein, GST-tagged Wheat Germ Human GST
ADAMTS18-303H Recombinant Human ADAMTS18 Protein, GST-tagged Wheat Germ Human GST
ADAMTS18-26HCL Recombinant Human ADAMTS18 cell lysate Human Non
ADAMTS18-326M Recombinant Mouse ADAMTS18 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ADAMTS18-326M-B Recombinant Mouse ADAMTS18 Protein Pre-coupled Magnetic Beads HEK293 Mouse
ADAMTS18-4326H Recombinant Human ADAMTS18 protein(913-1040aa), His-GST&Myc-tagged E.coli Human N-His-GST&C-Myc 913-1040aa
ADAMTS18-4728H Recombinant Human ADAMTS18 protein, His-tagged E.coli Human His 942-1047aa
ADAMTS18-918HF Recombinant Full Length Human ADAMTS18 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 415 amino acids
gag-4101H Recombinant HIV-1 gag protein, GST-tagged E. coli Human N-GST 133-363 aa
gag-4102H Recombinant HIV-1 gag protein, His-tagged E. coli Human N-His 133-363 aa

    Involved Pathway

    ADAMTS18 involved in several pathways and played different roles in them. We selected most pathways ADAMTS18 participated on our site, such as Degradation of the extracellular matrix,Extracellular matrix organization,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Extracellular matrix organization SERPINH1,PPIB,CTS7,LTBP3,COL4A4,ELANE,DMP1,MFAP1B,CTSLL,JAM2B
    O-linked glycosylation MUC5AC,ADAMTSL4,ADAMTS8,MUC1,B3GALTL,ADAMTS15,KCNA6,GCNT3,ADAMTS20,ADAMTSL1
    Metabolism of proteins KIFC3,EXOSC8,EXOC6,ASNA1,TOMM22,HYOU1,SEC63,CST3,ZDHHC2,SPON1B
    O-glycosylation of TSR domain-containing proteins C8orf84,SPON2,ADAMTS3,THSD7A,ADAMTSL5,SPON1,THSD1,ADAMTS13,ADAMTS5,ADAMTS20
    Degradation of the extracellular matrix BMP1B,ELANE,MMP17,MMP11,MMP20,BSG,CTSL1,FURINA,TIMP2,MMP15
    Post-translational protein modification PIGK,NAPAB,EIF5A2,THSD7A,ALG10B,C8orf84,GALNT13,PHC2,MPDU1B,ADAMTS1

    Protein Function

    ADAMTS18 has several biochemical functions, for example, metalloendopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS18 itself. We selected most functions ADAMTS18 had, and list some proteins which have the same functions with ADAMTS18. You can find most of the proteins on our site.

    Function Related Protein
    metalloendopeptidase activity YME1L1,PAPPAB,UQCRC1,MMP23BB,ADAM25,MIPEP,ADAMTS12,ADAM32,MMP15,ADAMTS3
    zinc ion binding CRIP2,ZNF276,ZNFL1,MKRN2,ADAT3,PIAS4A,ANPEPB,PDZRN4,ZEB1,MMP14B

    Interacting Protein

    ADAMTS18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS18 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS18.

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