ADAMTS18
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 18 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. -
Synonyms
ADAMTS18;ADAM metallopeptidase with thrombospondin type 1 motif, 18;a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 , ADAMTS21;A disintegrin and metalloproteinase with thrombospondin motifs 18;ADAMTS 18;ADAMTS21;EC 3.4.24.;ADAM-TS18;ADAMTS-18;ADAM-TS 18;disintegrin and metalloprotease-like protein;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21;KNO2
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- Myc
Involved Pathway
ADAMTS18 involved in several pathways and played different roles in them. We selected most pathways ADAMTS18 participated on our site, such as Degradation of the extracellular matrix,Extracellular matrix organization,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Post-translational protein modification | ARSH,KCNA6,CNIH,ALG2,ATPBD4,GALNTL5,DOHH,STT3A,MAN1A2,ARSJ |
| Metabolism of proteins | APCS,SLC38A8,PAM16,PAPPA2,DNAJC24,ARSD,SFTPB,TIMM23,TIMM50,ADAMTS3 |
| O-linked glycosylation | B3GALTL,C8orf84,GALNT5,MUC1,ADAMTS13,ADAMTSL5,ADAMTS15,MUCL1,B3GNT2A,MUC4 |
| Degradation of the extracellular matrix | LOC100686744,TLDC2,CAPNS1,TLL2,ADAMTS8,MMP20,COL17A1,CTRB1,MMP10,MMP13 |
| Extracellular matrix organization | CTRB1,SERPINH1,FAM49BA,COL13A1,LOX,MATN3,PCOLCE2B,HAPLN1,COL8A1A,SERPINH1A |
| O-glycosylation of TSR domain-containing proteins | ADAMTS20,ADAMTS1,ADAMTSL4,SPON1A,SPON2,ADAMTS13,THSD1,ADAMTS3,ADAMTS5,C8orf84 |
Protein Function
ADAMTS18 has several biochemical functions, for example, metalloendopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS18 itself. We selected most functions ADAMTS18 had, and list some proteins which have the same functions with ADAMTS18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | PAPPAB,ADAM8A,MMP15,ZMPSTE24,PAPPAA,MIPEP,PHEX,ADAM30,MEP1A.1,MMP20 |
| zinc ion binding | PGLYRP3,POLR3K,FTR14,TRAF2,RARAA,ZFYVE20,TRIM14,RARG,RNPEP,MYLIP |
Interacting Protein
ADAMTS18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS18 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS18.
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