ACAA1
-
Official Full Name
acetyl-CoA acyltransferase 1 -
Overview
This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. -
Synonyms
ACAA1;acetyl-CoA acyltransferase 1;acetyl Coenzyme A acyltransferase 1;3-ketoacyl-CoA thiolase, peroxisomal;peroxisomal 3 oxoacyl Coenzyme A thiolase;beta-ketothiolase;peroxisomal 3-oxoacyl-CoA thiolase;acetyl-Coenzyme A acyltransferase 1;peroxiso
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- E.coli
- E. coli
- Wheat Germ
- Mammalian Cell
- Insect Cell
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- GST
- N-GST
- His
- Non
- Flag
- His&Fc&Avi
- His&SUMO
- Myc&DDK
Involved Pathway
ACAA1 involved in several pathways and played different roles in them. We selected most pathways ACAA1 participated on our site, such as Fatty acid degradation,Valine, leucine and isoleucine degradation,alpha-Linolenic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACAA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Valine, leucine and isoleucine degradation | ALDH7A1,ALDH6A1,ACADM,ALDH3A2,OXCT2B,HADHAB,AUH,BCAT2,ALDH9A1A.1,AOX3L1 |
| alpha-Linolenic acid metabolism | PLA2G2E,PLA2G4C,PLA2G2A,PLA2G4D,PLA2G12A,PLA2G10,ACAA1A,ACOX1,PLA2G4A,PLA2G2F |
| PPAR signaling pathway | GK,CYP7A1A,MMP1A,CYP4A12A,FABP1,PPARA,ACOX3,ACAA1A,APOC3,GK2 |
| Metabolic pathways | APRT,EXTL1,HPD,GCNT2,PIP5K1AB,SMPD2A,AMY2A3,RPN2,MAT1A,GPAA1 |
| Fatty acid metabolism | CPT2,HSD17B12,CPT1C,ACOX1,ACSL1B,ACADVL,SCDB,ACADS,ELOVL6,OXSM |
| Fatty acid degradation | ACAA1A,ADH1,CPT1A,ALDH9A1A.1,CPT1B,ACSL3A,CYP4A11,ACSL1B,PECI,ALDH9A1B |
| Biosynthesis of unsaturated fatty acids | Scd1,ELOVL5,ACOT5,TECRB,PTPLA,ELOVL2,HSD17B12,ACOX1,PTPLAD1,SCD5 |
| Peroxisome | SLC27A2,IDH1,ACSL1,SOD2,MPV17,AGXTB,PEX19,ACSL4A,ECI2,CROT |
Protein Function
ACAA1 has several biochemical functions, for example, acetyl-CoA C-acyltransferase activity,palmitoyl-CoA oxidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACAA1 itself. We selected most functions ACAA1 had, and list some proteins which have the same functions with ACAA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| palmitoyl-CoA oxidase activity | ACAA1A,ACOX1,ACOXL,ACADL |
| acetyl-CoA C-acyltransferase activity | HADHB,ACAA1A,ACAA2 |
| protein binding | LIMD1,PIK3R6,THEMIS2,TBC1D24,MTMR2,PAX3,SEC63,NCOR2,AKTIP,HGF |
Interacting Protein
ACAA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACAA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACAA1.
TXNDC11;ere_dna
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