WISP2
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Official Full Name
WNT1 inducible signaling pathway protein 2 -
Overview
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. -
Synonyms
WISP2;WNT1 inducible signaling pathway protein 2;WNT1-inducible-signaling pathway protein 2;CCN5;CT58;CTGF L;CCN family member 5;Connective tissue growth factor like protein;Connective tissue growth factor related protein 58;Connective tissue growth factor-like protein;Connective tissue growth factor-related protein 58;CTGF-L;WISP 2;WISP-2;WISP2_HUMAN;OTTHUMP00000031770;OTTHUMP00000063227;wnt-1 signaling pathway protein 2
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Human
- Mammalian Cell
- HEK293
- Yeast
- Non
- His
- GST
- His&SUMO
- His&Fc&Avi
Involved Pathway
WISP2 involved in several pathways and played different roles in them. We selected most pathways WISP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with WISP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
WISP2 has several biochemical functions, for example, heparin binding,insulin-like growth factor binding,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WISP2 itself. We selected most functions WISP2 had, and list some proteins which have the same functions with WISP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | ITGA3,PXN,WISP1B,PTPN2,TLN1,SEMA7A,ECM2,CYR61,L1CAM,GPNMB |
| insulin-like growth factor binding | IGFALS,IGFBP2A,HTRA3,IGF1RB,WISP1B,IGF1RA,HTRA1,IGFBP7,CTGFA,CTGFB |
| heparin binding | PTPRFB,RSPO1,FGF1A,PF4V1,LPL,APOE,ECM2,HSD17B12,WISP1A,ADAMTS8 |
Interacting Protein
WISP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WISP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of WISP2.
TFAP2A;syd;fliH;TFAP2C
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