WIF1
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Official Full Name
WNT inhibitory factor 1 -
Overview
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010] -
Synonyms
WIF1;WNT inhibitory factor 1;WIF-1
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Insect Cells
- Hi-5 Insect Cells
- Human Cells
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
WIF1 involved in several pathways and played different roles in them. We selected most pathways WIF1 participated on our site, such as Negative regulation of TCF-dependent signaling by WNT ligand antagonists,Presenilin action in Notch and Wnt signaling,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with WIF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Wnt | FMNL3,GPR177,SOX32,SRY,LGR6,PRICKLE1B,TMED5,KLHL12,RBBP5,ASH2L |
| Wnt signaling network | IGFBP4,CTHRC1,RSPO1,ATP6AP2,RYK |
| Presenilin action in Notch and Wnt signaling | TLE1,AES,KREMEN2 |
| Signal Transduction | ARHGAP40,MYO7A,ARHGAP22,PDK3B,PTPRK,ROPN1,PROKR1,IFT88,USP34,GPR161 |
| Negative regulation of TCF-dependent signaling by WNT ligand antagonists | KREMEN2,KREMEN1 |
| TCF dependent signaling in response to WNT | RSPO3,WNT8-2,PYGO2,SOX9B,SOX13,LEO1,LGR6,SOX4B,BCL9,SOX4A |
| Wnt signaling pathway | WNT2,SIAH1A,FBXW11,FZD1,DAAM1B,FZD3A,INVS,MAPK8A,PPARD,TCF7 |
Protein Function
WIF1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WIF1 itself. We selected most functions WIF1 had, and list some proteins which have the same functions with WIF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | IGFBP5,NACC2,BUD13,CRYGD,KLC4,SRSF5,SP140,VEGFAB,STK38,CTSB |
Interacting Protein
WIF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WIF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WIF1.
KRTAP10-8;Wnt5a;Wnt3a
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