USP10
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Official Full Name
ubiquitin specific peptidase 10 -
Overview
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and;degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme;specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and;cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in;the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. -
Synonyms
USP10;ubiquitin specific peptidase 10;ubiquitin specific protease 10;ubiquitin carboxyl-terminal hydrolase 10;KIAA0190;UBPO;ubiquitin thioesterase 10;deubiquitinating enzyme 10;ubiquitin thiolesterase 10;ubiquitin-specific-processing protease 10
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- E.coli
- Insect Cell
- Mammalian Cell
- HEK293
- GST
- Flag
- His
- His&SUMO
- Non
- His&Strep
- His&Fc&Avi
Involved Pathway
USP10 involved in several pathways and played different roles in them. We selected most pathways USP10 participated on our site, such as DNA Damage Bypass,DNA Repair,Termination of translesion DNA synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with USP10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Termination of translesion DNA synthesis | USP43,KIAA0101,USP43A,POLI |
| DNA Damage Bypass | POLI,ZBTB32,SPRTN,POLD3,USP43A,DDB1,MAD2L2,USP43,KIAA0101,UBE2L6 |
| Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template | USP43A,USP43,POLI,SPRTN,KIAA0101 |
| DNA Repair | RAD17,RAD51AP1,MAD2L2,TDP2B,COPS8,COPS7A,POLI,KDM4A,RAD9A,RHNO1 |
Protein Function
USP10 has several biochemical functions, for example, cysteine-type endopeptidase activity,ion channel binding,p53 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by USP10 itself. We selected most functions USP10 had, and list some proteins which have the same functions with USP10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-specific protease activity | ZRANB1,USP19,OTUD4,OTUD3,USP16,ATXN3L,USP5,USP4,USP8,USP3 |
| protein binding | NXT2,HACE1,TFRC,VARS2,BACE1,CRLF1,RPL13,RGS14,ASNA1,ALKBH3 |
| ion channel binding | PDE4B,KCNH1,ACTN4,AKAP6,AASS,SRC,VDAC1,CALM,TCAP,KCNE1L |
| poly(A) RNA binding | PUF60,ALG13,SRPK2,DHX36,MAGOHB,SNRNP40,NQO1,TRMT1,HUWE1,LUZP4 |
| p53 binding | BLM,NTRK3,SIRT1,AXIN1,GSK3B,ZMAT4,PSME3,TP53,TRIM24,CDKN2AIP |
| cysteine-type endopeptidase activity | MALT1,Casp3,DUB1,CTSF,CTSL1,USP13,USP1,USP12A,CASPB,USP24 |
Interacting Protein
USP10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP10 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP10.
G3BP2;YBX1;ZC3H12A;EIF4G3;ULK1;G3BP1;EIF4G1 variant protein;CELF1;GAR1;RAD51
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References
- Feng, AP; He, YM; et al. Expression of USP15, T beta R-I and Smad7 in psoriasis. JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES 34:415-419(2014).
- Dauphinee, SM; Richer, E; et al. Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections. GENES AND IMMUNITY 15:282-292(2014).
