UBE2M
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Official Full Name
ubiquitin-conjugating enzyme E2M -
Overview
Similar to ubiquitin, Nedd8 signals to target proteins through an enzymatic cascade composed of Nedd8-specific E1 (activating)- and E2 (conjugating)-enzymes. The E2 ligase specific for Nedd8 is Ubc12. Ubc12 forms a heterodimeric conjugate with NEDD8 in or -
Synonyms
UBE2M;ubiquitin-conjugating enzyme E2M;ubiquitin conjugating enzyme E2M (homologous to yeast UBC12) , ubiquitin conjugating enzyme E2M (UBC12 homolog, yeast);NEDD8-conjugating enzyme Ubc12;hUbc12;UBC12;yeast UBC12 homolog;NEDD8 protein ligase;NED
Recombinant Proteins
- Human/Mouse/Rat
- Human
- Rhesus macaque
- E. coli
- E.coli
- Human
- Mammalian Cell
- HEK293
- Non
- His
- His&Fc&Avi
Involved Pathway
UBE2M involved in several pathways and played different roles in them. We selected most pathways UBE2M participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CUL3A,SAE1,MID1,ANAPC1,CUL3,KEAP1B,CUL4A,HERC3,UBE2G1A,FBXO4 |
Protein Function
UBE2M has several biochemical functions, for example, ATP binding,NEDD8 transferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2M itself. We selected most functions UBE2M had, and list some proteins which have the same functions with UBE2M. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ribosomal S6-glutamic acid ligase activity | TMEM129,RNF149,G2E3,NEURL1B,MUL1A,MARCH6,ARIH1L,MARCH4,RFWD2,RAG1 |
| protein binding | AP5Z1,CRB1,IFRD2,APOA1,DNAI2,LURAP1,FTH1,KLHDC5,ACVR1,RAB7A |
| ATP binding | ACSF2,GALK2,NRBP2,UHMK1,HSP90B1,ABCB1A,AK7,HARS,CLK2A,CHEK2 |
| NOT ubiquitin protein ligase activity | UBE2I,UBE2F,UBE2IA,VHLL,UBE2IB |
| NOT ubiquitin protein ligase binding | UBE2IB,UBE2F,UBE2IA,UBE2I |
| ubiquitin-protein transferase activity | RNF125,TRIM28,FBXO30B,RNF43,UBE2D1,LTN1,LNX2B,PARK2,TOPORS,RBBP6 |
| NEDD8 transferase activity | UBE2F,RNF7,RBX1 |
Interacting Protein
UBE2M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2M here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2M.
CUL1;NEDD8;UBA3;FBXO11;CUL5;51473135;PRKAR1A;MCC;CDK2
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