UBB
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Official Full Name
ubiquitin B -
Overview
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. -
Synonyms
UBB;FLJ25987;MGC8385;OTTHUMP00000064960;OTTHUMP00000064961;UBA80;UBCEP1;UBCEP2;polyubiquitin B;ubiquitin B;polyubiquitin B.
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Chicken
- Rat
- E. coli
- E.coli
- Mammalian Cell
- Mouse
- HEK293
- His
- GST
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
UBB involved in several pathways and played different roles in them. We selected most pathways UBB participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | VDAC2,ATP5A1,UQCR10,MT-ND1,PPIF,SDHC,PINK1,NDUFV1,MT-ATP6,UCHL1 |
Protein Function
UBB has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBB itself. We selected most functions UBB had, and list some proteins which have the same functions with UBB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CKB,NUDT4,UBXN6,LACTB2,BSX,RAB7A,ZBTB7B,ITGB1BP3,PHB,KCNMB4 |
Interacting Protein
UBB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBB here. Most of them are supplied by our site. Hope this information will be useful for your research of UBB.
TP53;PSMD4
Resources
Research Area
Parkinson's Disease Related MoleculesUbiquitin
Post-translational Modification of NFkB/IkB
Wnt Intracellular Signaling
Related Services
Related Products
References
- Seidel, K; Meister, M; et al. Cellular protein quality control and the evolution of aggregates in spinocerebellar ataxia type 3 (SCA3). NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 38:548-558(2012).
- Patrick, S; Jobling, KL; et al. A unique homologue of the eukaryotic protein-modifier ubiquitin present in the bacterium Bacteroides fragilis, a predominant resident of the human gastrointestinal tract. MICROBIOLOGY-SGM 157:3071-3078(2011).
Reviews
The protein has been working pretty well for us. I will definitely reach out to order more.
