TNFRSF1B
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Official Full Name
tumor necrosis factor receptor superfamily, member 1B -
Overview
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008] -
Synonyms
TNFRSF1B;tumor necrosis factor receptor superfamily, member 1B;p75;TBPII;TNFBR;TNFR2;CD120b;TNFR1B;TNFR80;TNF-R75;p75TNFR;TNF-R-II;tumor necrosis factor receptor superfamily member 1B;TNF-R2;TNF-RII;p75 TNF receptor;p80 TNF-alpha receptor;soluble TNFR1B variant 1;tumor necrosis factor receptor 2;tumor necrosis factor beta receptor;tumor necrosis factor receptor type II;tumor necrosis factor binding protein 2
Recombinant Proteins
- Human
- Mouse
- Cynomolgus/Rhesus
- Rhesus macaque
- Zebrafish
- Chicken
- Rat
- Cynomolgus
- Mus musculus
- HEK293
- E.coli
- Mammalian Cells
- Human Cells
- Insect Cells
- CHO
- Yeast
- Fc&His
- His
- Fc
- Non
- GST&His
- His&T7
- Avi&His
- Avi&Fc&His
- mFc
- GST
Involved Pathway
TNFRSF1B involved in several pathways and played different roles in them. We selected most pathways TNFRSF1B participated on our site, such as Cytokine-cytokine receptor interaction,TNF signaling pathway,Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | STAT3,PCK1,PRKAB2,ACSL1B,RXRBA,CPT1C,IKBKB,SOCS3B,PCK2,NFKBIA |
| Cytokine-cytokine receptor interaction | IL28A,CCL4,CLCF1,LIFR,PDGFC,CCL1,TNFSF8,IL25,MPL,IFNB |
| TNF signaling pathway | TAB2,RIPK1,BIRC3,MAPK8,CXCL5,MAGI2,MAPK1,CASP7,SELE,PIK3CA |
| Amyotrophic lateral sclerosis (ALS) | MAP2K6,CASP9,GPX1,Casp3,GRIA2,PRPH,ALS2,GRIN2B,NOS1,MAPK11 |
Protein Function
TNFRSF1B has several biochemical functions, for example, protein binding,tumor necrosis factor-activated receptor activity,ubiquitin protein ligase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF1B itself. We selected most functions TNFRSF1B had, and list some proteins which have the same functions with TNFRSF1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin protein ligase binding | PTPN22,PARK2,SMAD5,ATXN3,SUMO1,TNFRSF14,YWHAE,SCN5A,MAGEA2,TCEB2 |
| tumor necrosis factor-activated receptor activity | RELT,TNFRSF21,TNFRSF9A,FAS,TNFRSF10B,TNFRSFA,EDA2R,TNFRSF6B,NGFR,NGFRB |
| protein binding | Trf,EXO1,HELZ,HDDC3,PC,TGFBR2,BCDIN3D,GBP1,TTC33,CD8A |
Interacting Protein
TNFRSF1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF1B here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF1B.
GRN;TNF;TRAF2;TNF;TUBB3;HAX1;IRS4;CDIPT;XPO1;ATP2A1;IPO8;PHGDH;XPOT
TNFRSF1B Related Signal Pathway
Resources
Research Area
NeuroinflammationEndothelial Cell Markers
Diabetic Peripheral Neuropathy
T Cell Cytokine Signaling
CD Antigen (Helper T Cells)
TNF Receptor
Co-stimulatory Molecules
Related Services
Related Products
References
- Kolorz, M; Wroblova, K; et al. Pharmacogenomics of infliximab therapy, impact of TNFRSF1A and TNFRSF1B gene polymorphisms. BIOMEDICAL PAPERS-OLOMOUC 157:S75-S78(2013).
- Zhong, H; Bussel, J; et al. In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia. BRITISH JOURNAL OF HAEMATOLOGY 168:274-283(2015).
