SOX10
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Official Full Name
SRY (sex determining region Y)-box 10 -
Overview
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. -
Synonyms
SOX10;SRY (sex determining region Y)-box 10;transcription factor SOX-10;DOM;dominant megacolon;mouse;human homolog of;WS2E;WS4;SRY-related HMG-box gene 10;dominant megacolon, mouse, human homolog of;PCWH;WS4C;MGC15649
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- HEK293
- Mammalian Cell
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- HEK293T
- Mamanlian cells
- Myc&DDK
- His
- Non
- GST
- Flag
- His&Fc&Avi
Involved Pathway
SOX10 involved in several pathways and played different roles in them. We selected most pathways SOX10 participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neural Crest Differentiation | PMP22,MBP,HEY2,SOX5,CDH7,DLL3,ASCL1,CDH6,GBX2,HOXA1 |
Protein Function
SOX10 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX10 itself. We selected most functions SOX10 had, and list some proteins which have the same functions with SOX10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II transcription factor binding | LMO2,KLF14,CLOCK,PITX1,NOTCH1,GBX2,WWP2,NFE2L1,CREB1,NKX2-5 |
| transcription coactivator activity | MED31,FHL5,CITED4,TFAP2B,PRDM16,CREBBP,MTDH,TBPL1,MLL5,JUNBB |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | GLI3,NRL,KCNA3,MEOX1,SRF,HNRNPC,CDX4,SFPI1,NCOA2,CUX2 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | RFX3,MYOD1,GATA4,CREB1,MYF5,POU3F3,MITF,GATA6,JUN,USF2 |
| RNA polymerase II distal enhancer sequence-specific DNA binding | CREB1,MED12,ARX,PBX3,MIXL1,NFE2L2,TFAP2C,NR1H4,H3F3A,H3F3B |
| protein binding | RNF220,ITGAM,TEKT3,ACKR4,CTAGE5,CDC42EP2,ABCC2,GLYCTK,PEX5,STAG2 |
| transcription factor binding | HTT,CEBPA,PPRC1,DIP2C,IFI203,LEF1,PPARG,RPS3,TRP53,JUNB |
| chromatin binding | GPR30,FOS,CBX1,FLI1,PRDM11,TMPOA,RBMX,POLE,SUV39H1,SIN3B |
| identical protein binding | ST13,UBE2G2,OMG,PTPRM,DIAPH1,SH2B2,CIDEB,SCUBE1,SERPINA1,BRI3 |
Interacting Protein
SOX10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX10 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX10.
POU3F2;PAX3;UBE2I;SUMO1;CDK6;NMI;EXOC5
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References
- Cheng, WWC; Tang, CSM; et al. Depletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype. WORLD JOURNAL OF GASTROENTEROLOGY 21:2040-2046(2015).
- Willis, BC; Johnson, G; et al. SOX10: A Useful Marker for Identifying Metastatic Melanoma in Sentinel Lymph Nodes. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY 23:109-112(2015).
