SNAI1
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Official Full Name
snail homolog 1 -
Overview
Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells (1-3). -
Synonyms
SNAI1;snail homolog 1 (Drosophila);snail 1 (drosophila homolog), zinc finger protein;zinc finger protein SNAI1;SLUGH2;SNA;SNAH;SNAIL;SNAIL1;protein sna;snail 1 homolog;protein snail homolog 1;snail 1 zinc finger protein;snail 1, zinc finger p
Recombinant Proteins
- Mouse
- Human
- Chicken
- Mammalian Cell
- HEK293
- E.coli
- Wheat Germ
- Mamanlian cells
- HEK293T
- His
- Myc&DDK
- His&T7
- Non
- Flag
- His&Fc&Avi
Involved Pathway
SNAI1 involved in several pathways and played different roles in them. We selected most pathways SNAI1 participated on our site, such as Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adherens junction | PTPN1,WASL,ACTN1,TCF7,LEF1,NLK,WASF3,TGFBR2,ERBB2,ACP1 |
Protein Function
SNAI1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,kinase binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNAI1 itself. We selected most functions SNAI1 had, and list some proteins which have the same functions with SNAI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | CRYAB,ZFP428,NT5C3L,C1GALT1,TNK2,SAP30L,JADE1,KCND2,DAGLB,TOP2B |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | BCL11AA,KLF17,ZFP536,POU4F2,TCF3,TCF21,BATF3,ZNF148,NFIL3-4,HHEX |
| kinase binding | ABI2,JAKMIP1,PFKM,CHP,C2orf44,WWC1,GFAP,WWC2,CEBPA,LDHA |
| protein binding | TFAP2B,SLC16A3,KIAA1109,NDUFAF3,POLD1,CD36,TIMP1,SCIMP,HNRPDL,DDX5 |
| RNA polymerase II regulatory region sequence-specific DNA binding | FOXK1,BCL6,IRF2,FERD3L,GATA1,AEBP1,ZNF256,PRDM12B,XBP1,ALX1 |
Interacting Protein
SNAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SNAI1.
KDM1A
Resources
Research Area
Early Mesodermal Lineage MarkersSomite Markers
Cancer Stem Cell Transcription Factors
Epithelial Stem Cell Transcription Factors
Mesenchymal Stem Cell Transcription Factors
Neural Stem Cell Transcription Factors
Neural Crest Cell Markers
Pluripotent Stem Cell Transcription Factors
Ectodermal Lineage Markers
Mesodermal Lineage Markers
Related Services
Related Products
References
- Ohnuki, K; Umezono, T; et al. Expression of transcription factor Snai1 and tubulointerstitial fibrosis in progressive nephropathy. JOURNAL OF NEPHROLOGY 25:233-239(2012).
- Li, ZD; Wermuth, PJ; et al. Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition in Murine Pulmonary Endothelial Cells in Vitro. AMERICAN JOURNAL OF PATHOLOGY 182:325-331(2013).
