SIRT5
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Official Full Name
sirtuin 5 -
Overview
Sirtuin family of proteins that is important in aging, metabolism and disease. SIRT5 is expressed in a variety of tissues. Two different isoform have been described. Isoform 1 is reported to be express in the mitochondria and cytoplasm while isoform 2 appears to be localized to the mitochondria only. SIRT5 has also been linked to many primate-specific functions. SIRT5 has recently been implicated as having a role in adaptation to fasting, caloric restriction and high protein diets. -
Synonyms
SIRT5;sirtuin 5;sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 5;NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial;sir2-like 5;sirtuin type 5;SIR2-like protein 5;NAD-dependent deacetylase sirtuin-5;silent mating type information regulation 2, S.cerevisiae, homolog 5;SIR2L5;FLJ36950
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- HEK293T
- Insect Cell
- Mammalian cells
- His
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- His&Myc
- Flag
Involved Pathway
SIRT5 involved in several pathways and played different roles in them. We selected most pathways SIRT5 participated on our site, such as Signaling events mediated by HDAC Class I, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by HDAC Class I | GATA1,NR2C1,SIRT2,FKBP3,MXD1,PRMT5,TFCP2,SIRT4,WDR77,GATA2 |
Protein Function
SIRT5 has several biochemical functions, for example, NOT NAD+ ADP-ribosyltransferase activity,NAD+ binding,protein-glutaryllysine deglutarylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT5 itself. We selected most functions SIRT5 had, and list some proteins which have the same functions with SIRT5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT NAD+ ADP-ribosyltransferase activity | SIRT3,SIRT1,SIRT2 |
| zinc ion binding | NR2F2,GFI1AB,CBLC,APEX2,KDM2A,ING5A,GATA2B,PHF20L1,TRIM68,TNFAIP3 |
| NAD+ binding | ALDH1A3,SIRT7,SIRT2,SIRT4,GLUD1,SIRT6,SIRT1,HPGD,HADH,UXS1 |
Interacting Protein
SIRT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT5.
MYC;BAG6;HNRNPD;SGTB;SORT1
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