SIRPB1
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Official Full Name
signal-regulatory protein beta 1 -
Overview
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SIRPB1;signal-regulatory protein beta 1;signal-regulatory protein beta-1;CD172b;SIRP BETA 1;CD172 antigen like family member B;CD172b antigen;DKFZp686A05192;Signal regulatory protein beta 1;SIRP beta 1 isoform 3;OTTHUMP00000029992;OTTHUMP00000029993;OTTHUMP00000029994;CD172 antigen-like family member B;SIRP-BETA-1
Recombinant Proteins
- Human
- Insect Cell
- E.coli
- HEK293
- Mammalian cells
- Yeast
- HEK293T
- His
- Non
- Fc
- Flag
- His&Fc&Avi
- His&Avi
- Myc&DDK
Involved Pathway
SIRPB1 involved in several pathways and played different roles in them. We selected most pathways SIRPB1 participated on our site, such as Cell-Cell communication,DAP12 interactions,Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRPB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DAP12 interactions | FGF10B,PHB,AGO2,LCP2A,SIGLEC15,NRG2A,CD300E,SIGLEC14,NRG4,ADRBK1 |
| Cell-Cell communication | CDH18,JUPA,SPTBN1,KIRREL,CDH5,CDH2,CDH10,DST,CADM2B,CDH4 |
| Signal regulatory protein (SIRP) family interactions | SKAP2 |
| Osteoclast differentiation | GRB2,MAPK12,CYBB,NFKB1,TGFBR2,PIK3CD,CSF1,MAPK11,SPI1,LILRB3 |
| Innate Immune System | SIGLEC15,DEFB121,IFI16,UNC93B1,BTR16,ART1,CLEC6A,BFB,CASP4,PPAPDC1B |
| Immune System | ACTR1B,ART1,CMTM2A,PANX1A,DEFB129,TXNIPB,IFIT10,TRIM11,ASB6,DZIP3 |
Protein Function
SIRPB1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRPB1 itself. We selected most functions SIRPB1 had, and list some proteins which have the same functions with SIRPB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MPHOSPH8,LILRB3,SKA3,HIF1A,SGCA,BCCIP,VPS33B,ZNF423,FOXRED2,HSF1 |
Interacting Protein
SIRPB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRPB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRPB1.
TYROBP;SYK;Syk
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesDendritic Cell ITIM/ITAM Immunoreceptors
Related Services
Related Products
References
- Nettleship, JE; Ren, JS; et al. Crystal structure of signal regulatory protein gamma (SIRP gamma) in complex with an antibody Fab fragment. BMC STRUCTURAL BIOLOGY 13:-(2013).
- Gaikwad, S; Larionov, S; et al. Signal Regulatory Protein-beta 1 A Microglial Modulator of Phagocytosis in Alzheimer's Disease. AMERICAN JOURNAL OF PATHOLOGY 175:2528-2539(2009).
