SIGLEC5
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Official Full Name
sialic acid binding Ig-like lectin 5 -
Overview
This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface;lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition;sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits;the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B;Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. -
Synonyms
SIGLEC5;sialic acid binding Ig-like lectin 5;CD33L2;sialic acid-binding Ig-like lectin 5;CD170;OB BP2;SIGLEC 5;CD33 antigen-like 2;OB-binding protein 2;obesity-binding protein 2;sialic acid-binding immunoglobulin-like lectin 5;OBBP2;OB-BP2;SI
Recombinant Proteins
- Human
- Rhesus macaque
- Insect Cell
- E.coli
- Mammalian cells
- C-His-Avi
- HEK293
- Human Cell
- E.coli expression system
- HEK293T
- His&Fc
- His
- Fc
- Non
- His&S
- His&Avi
- His&Fc&Avi
- Fc&Avi
- Myc&DDK
Involved Pathway
SIGLEC5 involved in several pathways and played different roles in them. We selected most pathways SIGLEC5 participated on our site, such as Adaptive Immune System,Immune System,Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIGLEC5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | CD160,KIF20A,LRSAM1,LAIR2,STIM1B,ASB7,LCP2A,TRIM63,SEC61B,SPSB2 |
| Immune System | ASB3,LILRA3,UBE2U,CTS7,RNF34,KLRB1A,IFIT12,CYBA,SEC24A,CTSD |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | ICAM4,LILRA2,KLRB1B,LILRA3,KLRG1,AF251705,LILRA1,CD160,OSCAR,SIGLEC6 |
Protein Function
SIGLEC5 has several biochemical functions, for example, carbohydrate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIGLEC5 itself. We selected most functions SIGLEC5 had, and list some proteins which have the same functions with SIGLEC5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | LGALS9,LGALS9L1,SIGLEC10,CD209C,BCAN,LGALS9C,OS9,CLEC4M,ASGR2,LMAN1L |
| protein binding | NOS1AP,BAZ2A,ZRANB1,XRN1,SCO1,MAP3K7IP3,RINT1,DCTN3,TTC37,PKM |
Interacting Protein
SIGLEC5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIGLEC5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIGLEC5.
TRIP13;VAC14;q7cjv9_yerpe
Resources
Research Area
ITIM/ITAM Immunoreceptors and Related MoleculesMyeloid Cell
Neutrophils
Ig-type Lectins
Dendritic Cell Activation
Dendritic Cell ITIM/ITAM Immunoreceptors
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References
