SETD2
-
Official Full Name
SET domain containing 2 -
Overview
Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008] -
Synonyms
SETD2;SET domain containing 2;HYPB;SET2;HIF-1;HIP-1;KMT3A;HBP231;HSPC069;p231HBP;histone-lysine N-methyltransferase SETD2;huntingtin yeast partner B;lysine N-methyltransferase 3A;huntingtin interacting protein 1;huntingtin-interacting protein B
Recombinant Proteins
- Human
- Mouse
- Insect Cell
- Sf9 Insect Cell
- Mammalian Cell
- E.coli
- Rabbit
- HEK293
- GST
- Flag
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SETD2-199H |
Active Recombinant Human SETD2 protein, GST-tagged
|
Insect Cell | Human | GST | 1425-1717 a.a. |
|
| SETD2-69H |
Active Recombinant Human SETD2, FLAG-tagged
|
Sf9 Insect Cell | Human | Flag | 1392-2564 a.a. |
|
| SETD2-14979M | Recombinant Mouse SETD2 Protein | Mammalian Cell | Mouse | His |
|
|
| SETD2-188H | Recombinant Human SETD2 Protein, GST-tagged | E.coli | Human | GST | 1433-1711 |
|
| SETD2-189H | Recombinant Human SETD2 Protein, His-tagged | E.coli | Human | His | 1433-1711 |
|
| SETD2-259H | Recombinant Human SETD2 protein | E.coli | Human | Non | 1345-1711 a.a. |
|
| SETD2-260H | Recombinant Human SETD2 protein, GST-tagged | E.coli | Human | GST | 1345-1711 a.a. |
|
| SETD2-27850TH | Active Recombinant Human SETD2 Protein | E.coli | Human | Non | 915-1211 a.a. |
|
| SETD2-460H | Recombinant Human SET Domain Containing 2, GST-tagged | E.coli | Human | GST | 915-1211 a.a. |
|
| SETD2-461H | Recombinant Human SETD2, GST-tagged | E.coli | Human | GST | 1418-1714 a.a. |
|
| CPBT-38347RH | Rabbit Anti-Human SETD2 Polyclonal Antibody | Rabbit | Human | Non |
|
|
| Kit-1864 | SETD2 Chemiluminescent Assay Kit | Non |
|
|||
| SETD2-023H | Recombinant Human SETD2 Protein, His-tagged | E.coli | Human | His | 1435-1711 |
|
| SETD2-116H | Recombinant Human SETD2 Protein, His-tagged | E.coli | Human | His | 1435-1711 |
|
| SETD2-8067M | Recombinant Mouse SETD2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| SETD2-8067M-B | Recombinant Mouse SETD2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
SETD2 involved in several pathways and played different roles in them. We selected most pathways SETD2 participated on our site, such as Lysine degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SETD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysine degradation | EHMT2,ALDH7A1,DLST,HYKK,MLL5,HADHA,WHSC1L1,SUV39H1,EHHADH,SETDB2 |
Protein Function
SETD2 has several biochemical functions, for example, histone methyltransferase activity (H3-K36 specific),histone-lysine N-methyltransferase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SETD2 itself. We selected most functions SETD2 had, and list some proteins which have the same functions with SETD2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histone-lysine N-methyltransferase activity | SETD1B,EHMT1,SMYD1,SUV39H1B,EZH1,SETD8A,SMYD2B,EHMT1B,SETD8,SETD8B |
| histone methyltransferase activity (H3-K36 specific) | SETD3,ASH1L,SMYD2A,SETMAR,SMYD2,SMYD2B,NSD1 |
| protein binding | NOSTRIN,IRF2BP1,ZKSCAN1,RAB23,CATSPERG2,RAB2A,HOXB9,ARHGAP5,MAPK15,ATP2B4 |
Interacting Protein
SETD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SETD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SETD2.
SMAD3;SIAH2;HTT;ATXN1;fdoH;argS;CIC;q9wmx2-pro_0000037541;q9wmx2-pro_0000037544;q9wmx2-pro_0000037545;q9wmx2-pro_0000037547;q9wmx2-pro_0000037552;Soga1;Ttll7;CLK2;RASSF8
Resources
Research Area
Tumor SuppressorsIntracellular Factors in Inflammation
Transcription Factors in the Akt Pathway
ROS and Stress Resistance
Cancer Stem Cell Transcription Factors
Hematopoietic Stem Cell Transcription Factors and Regulators
Intracellular Signaling Molecules in Angiogenesis
Related Services
Related Products
References
- Newbold, RF; Mokbel, K; et al. Evidence for a Tumour Suppressor Function of SETD2 in Human Breast Cancer: A New Hypothesis. ANTICANCER RESEARCH 30:3309-3311(2010).
