RSPO2
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Official Full Name
R-spondin 2 -
Overview
R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008] -
Synonyms
RSPO2;R-spondin 2;CRISTIN2;R-spondin-2;R-spondin 2 homolog;roof plate-specific spondin-2
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- CHO
- HEK293
- E.coli
- Mammalian cells
- Mammalian Cell
- HEK293T
- Human Cell
- Mamanlian cells
- Non
- Fc
- His
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
RSPO2 involved in several pathways and played different roles in them. We selected most pathways RSPO2 participated on our site, such as Regulation of FZD by ubiquitination,Signal Transduction,Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with RSPO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TCF dependent signaling in response to WNT | SOX4A,SRY,KLHL12,SOX6,LGR4,PYGO2,USP34,ASH2L,RBBP5,HECW1B |
| Regulation of FZD by ubiquitination | RNF43,RSPO1,LGR6,LGR4,ZNRF3,RSPO3,FMNL3,LGR5,RSPO4 |
| Signaling by Wnt | CCDC88C,PYGO1,TLE3B,WNT8-2,RBBP5,ASH2L,LEO1,LGR6,PRICKLE1B,CSNK1G2 |
| Signal Transduction | PPEF1,FMNL2,DEPDC1B,ADCYAP1B,ARHGAP4,LINGO1,KIF14,RGS10,ABHD6B,RTKN |
Protein Function
RSPO2 has several biochemical functions, for example, G-protein coupled receptor binding,heparin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RSPO2 itself. We selected most functions RSPO2 had, and list some proteins which have the same functions with RSPO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor binding | WNT11R,HLA-F,LGI1,MATK,NPPB,RAB8B,PVRL2,CADM1B,RND1,MLYCD |
| G-protein coupled receptor binding | GNAV1,SAA1,USP33,GNAI2A,ITGB4,PSAPL1,NPFFL,ARHGEF12,INSL3,FCN1 |
| heparin binding | PLA2G2D,SELL,HDGF,Itgam&Itgb2,NRP1A,THBS3,FGFR2,AZU1,APPA,ABI3BP |
| protein binding | EZH2,MOCOS,PPP3CB,CXCL10,RAB14,TEKT5,ZNF622,CD93,EFNB1,FSTL1 |
Interacting Protein
RSPO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RSPO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RSPO2.
KRTAP10-4;KRTAP10-7;KRTAP10-9;PLEKHF2;SUV39H1;JMJD6
RSPO2 Related Signal Pathway
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