Pde10a
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Official Full Name
PDE10A phosphodiesterase 10A -
Overview
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal;transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP;and cGMP to the corresponding nucleoside 5 monophosphate, but has higher affinity for cAMP, and is more efficient;with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. -
Synonyms
PDE10A;phosphodiesterase 10A;cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A;phosphodiesterase 10A1 (PDE10A1);dJ416F21.1 (phosphodiesterase 10A);HSPDE10A;FLJ11894;FLJ25677
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
Pde10a involved in several pathways and played different roles in them. We selected most pathways Pde10a participated on our site, such as G alpha (s) signalling events,GPCR downstream signaling,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pde10a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitric oxide stimulates guanylate cyclase | KCNMA1,KCNMB2,KCNMB1 |
| G alpha (s) signalling events | GPBAR1,GHRH,CRHB,CALCB,RAMP3,INSL3,CGA,ADRB3,PTHRP2,GCGB |
| Signal Transduction | NPSR1,RDH14B,GPR55,CXCL11.8,QRFPR,WIPF2,PCSK6,SKILB,RDH14A,RNF41 |
| GPCR downstream signaling | PYY,NMUR1,MCF2L,GRP,ANXA1,ADORA3,HRH3,HCAR1-2,UTS2,RGS7 |
| Hemostasis | Alb,SLC3A2B,TFA,GATA1A,PIK3R6,IRF2A,CABLES2,TRPC6A,MFN2,HBBE2 |
| Platelet homeostasis | KCNMA1,KCNMB1,KCNMB2,APOER2,ATP2B1B,SLC8A2A,ATP2B3A |
| Purine metabolism | NME2,NUDT2,POLR2D,NPR1A,POLR3GL,ITPA,GUCY2F,AK9,POLR3A,NT5E |
Protein Function
Pde10a has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity,3,5-cyclic-nucleotide phosphodiesterase activity,cAMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Pde10a itself. We selected most functions Pde10a had, and list some proteins which have the same functions with Pde10a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug binding | MT2A,CYP2C9,GSTP2,CYP2D6,FOLR1,CHRNA7,PIGC,CNR1,CHRNA2,PPP3CB |
| cGMP-stimulated cyclic-nucleotide phosphodiesterase activity | TDP2B,PDE11A,PDE2A,USB1 |
| cGMP binding | CNGA1,CNGA2,PDE11A,CNGA3,PDE6C,PRKG1,PRKG1A,PDE6G,PDE6H,PRKG2 |
| cAMP binding | PDE4B,PRKAR1B,PDE3A,PRKAR2A,PDE11A,RAPGEF4,HCN2,CNGA4,RAPGEF3,PDE4D |
| 3,5-cyclic-nucleotide phosphodiesterase activity | PDE5A,PDE11A,PDE6D,PDE4D,PDE8B,PDE9A,PDE5AB,PDE8A,PDE3B |
| metal ion binding | ZFP93,NCALDA,PDE5AB,LEPREL1,ZNF580,EIF2S2,CMC1,ENTPD8,NPTXR,PPM1LA |
| 3,5-cyclic-GMP phosphodiesterase activity | PDE9A,PDE6A,PDE6B,PDE6G,PDE11A,PDE5A,PDE6H,PDE6C |
Interacting Protein
Pde10a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pde10a here. Most of them are supplied by our site. Hope this information will be useful for your research of Pde10a.
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References
- Guez-Barber, D; Fanous, S; et al. FACS purification of immunolabeled cell types from adult rat brain. JOURNAL OF NEUROSCIENCE METHODS 203:10-18(2012).
- Charych, EI; Jiang, LX; et al. Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia. JOURNAL OF NEUROSCIENCE 30:9027-9037(2010).
