PSMA7
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Official Full Name
proteasome (prosome, macropain) subunit, alpha type, 7 -
Overview
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. This particular subunit has been shown to interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. In addition, this subunit is involved in regulating hepatitis virus C internal ribosome entry site (IRES) activity, an activity essential for viral replication. This core alpha subunit is also involved in regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. Multiple isoforms of this subunit arising from alternative splicing may exist but alternative transcripts for only two isoforms have been defined. A pseudogene has been identified on chromosome 9. -
Synonyms
PSMA7;proteasome (prosome, macropain) subunit, alpha type, 7;proteasome subunit alpha type-7;C6;HSPC;proteasome subunit RC6 1;proteasome subunit XAPC7;RC6 1;XAPC7;proteasome subunit RC6-1;proteasome subunit alpha 4;RC6-1;MGC3755
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Human
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PSMA7 involved in several pathways and played different roles in them. We selected most pathways PSMA7 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMB4,SHFM1,PSMD4B,IFNG,PSMB11,PSMD4A,PSMD11B,PSMD7,PSMD11A,PSMD6 |
Protein Function
PSMA7 has several biochemical functions, for example, endopeptidase activity,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMA7 itself. We selected most functions PSMA7 had, and list some proteins which have the same functions with PSMA7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | PSEN1,MME,MMP3,KLK1B11,AP1S2,PSMB11,PSMA1,MMP9,PSMA6,NCSTN |
| protein binding | NXF2,HRASLS5,BNIPL,CIZ1,ADCK3,WEE1,COMMD10,FASLG,EGFR,NAIF1 |
| threonine-type endopeptidase activity | PSMA3,TASP1,PSMB9B,PSMB8F,PSMA2,PSMA8,PSMB9,PSMB9A,PSMB5,PSMB4 |
| identical protein binding | PLDN,MUL1,AMOTL2,ACTN2,MBIP,KCNRG,IK,IRF3,FTL,MRI1 |
Interacting Protein
PSMA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMA7.
PSMA1;PSMA3;PSMA4
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References
- Li, DP; Dong, QC; et al. c-Abl Regulates Proteasome Abundance by Controlling the Ubiquitin-Proteasomal Degradation of PSMA7 Subunit. CELL REPORTS 10:484-496(2015).
- Shimizu, N; Ueno, K; et al. Possible Role of ZPAC, Zygote-specific Proteasome Assembly Chaperone, During Spermatogenesis in the Mouse. JOURNAL OF REPRODUCTION AND DEVELOPMENT 60:179-186(2014).
