Recombinant Human Proteasome (prosome, macropain) Subunit, Alpha Type, 7, His-tagged

• Cat.No.: PSMA7-1444H
• Product Overview: PSMA7 Human Recombinant fused to N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 268 amino acids (1-248) and having a molecular mass of 30 kDa. PSMA7 is fused to a 20 amino acid His Tag at N-Terminus and purified by standard chromatography techniques.

Specification

• Cat. No.: PSMA7-1444H
• Description: PSMA7 interacts particularly with the hepatitis B virus X protein, a protein critical to viral replication. PSMA7 is involved in regulating hepatitis virus C internal ribosome entry site activity that is crucial for viral replication. PSMA7 is in charge for regulating the hypoxia-inducible factor-1alpha, a transcription factor important for cellular responses to oxygen tension. PSMA7 is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH.
• Source: Human
• Host: Escherichia Coli.
• Form: The PSMA7 solution contains 20 mM Tris-HCl pH-8, 0.1 M NaCl, and 20% glycerol.
• Purity: Greater than 90.0% as determined SDS-PAGE.
• Physical Appearance: Sterile Filtered colorless solution.
• Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSYDRAITVF SPDGHLFQVE YAQEAVKKGS TAVGVRGRDI VVLGVEKKSV AKLQDERTVR KICALDDNVC MAFAGLTADA RIVINRARVE CQSHRLTVED PVTVEYITRY IASLKQRYTQ SNGRRPFGIS ALIVGFDFDG TPRLYQTDPS GTYHAWKANA IGRGAKSVRE FLEKNYTDEA IETDDLTIKL VIKALLEVVQ SGGKNIELAV MRRDQSLKIL NPEEIEKYVA EIEKEKEENE KKKQKKAS
• Storage: PSMA7 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
• Protein length: 1-248 a.a.

Gene Information

• Gene Name: PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 [ Homo sapiens ]
• Official Symbol: PSMA7
• Synonyms: PSMA7; proteasome (prosome, macropain) subunit, alpha type, 7; C6; HSPC; RC6-1; XAPC7; MGC3755; proteasome subunit alpha type-7; OTTHUMP00000031449; OTTHUMP00000031450; OTTHUMP00000031453; proteasome subunit RC6-1; proteasome subunit XAPC7; proteasome subunit alpha 4
• Gene ID: 5688
• mRNA Refseq: NM_002792
• Protein Refseq: NP_002783
• MIM: 606607
• UniProt ID: O14818
• Chromosome Location: 20q13
• Pathway: APC/C:Cdc20 mediated degradation of Securin; Adaptive Immunity Signaling; Antigen processing: Ubiquitination & Proteasome degradation; Assembly of the pre-replicative complex; Apoptosis; Cell Cycle Checkpoints; Cell Cycle; DNA Replication; G1/S Transition; HIV Infection; Metabolism of RNA; Proteasome
• Function: identical protein binding; peptidase activity; protein binding; threonine-type endopeptidase activity